1354011-07-6 Usage
Description
((R)-1-Benzyl-piperidin-3-yl)-Methyl-aMine, a chemical compound with the molecular formula C15H22N2, is a derivative of piperidine featuring a benzyl group. ((R)-1-Benzyl-piperidin-3-yl)-Methyl-aMine possesses potential psychoactive and stimulant effects on the central nervous system, making it a compound of interest in the field of psychopharmacology.
Used in Pharmaceutical Industry:
((R)-1-Benzyl-piperidin-3-yl)-Methyl-aMine is used as a precursor in the synthesis of various psychoactive substances, particularly designer drugs. Its role in the creation of these substances is crucial, as it provides the foundation for developing new compounds with altered effects and potencies.
Used in Research and Development:
In the scientific community, ((R)-1-Benzyl-piperidin-3-yl)-Methyl-aMine is utilized for research purposes to explore its psychoactive properties and potential effects on the central nervous system. This helps in understanding its mechanisms of action and identifying possible therapeutic applications or risks associated with its use.
However, it is important to note that due to the psychoactive properties of ((R)-1-Benzyl-piperidin-3-yl)-Methyl-aMine, there may be potential for abuse and dependence. As such, further research is necessary to fully comprehend its pharmacological and toxicological profile, ensuring its safe and responsible application in any industry.
Check Digit Verification of cas no
The CAS Registry Mumber 1354011-07-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,4,0,1 and 1 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1354011-07:
(9*1)+(8*3)+(7*5)+(6*4)+(5*0)+(4*1)+(3*1)+(2*0)+(1*7)=106
106 % 10 = 6
So 1354011-07-6 is a valid CAS Registry Number.
1354011-07-6Relevant articles and documents
Design, synthesis and evaluation of (R)-3-(7-(methyl?7H-pyrrolo?2, 3-d]pyrimidin-4-yl)amino)-5-azaspiro?2.4]heptan-5-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor
Chough, Chieyeon,Lee, Sunmin,Joung, Misuk,Lee, Jaemin,Kim, Jong Hoon,Kim, B. Moon
, p. 477 - 489 (2018/03/28)
Based on (R)-N-methyl-N-(5-azaspiro?2.4]heptan-7-yl)-7H-pyrrolo?2, 3-d]pyrimidin-4-amine as a core scaffold, we identified (R)-3-(7-(methyl?7H-pyrrolo?2, 3-d]pyrimidin-4-yl)amino)-5-azaspiro?2.4]heptan-5- yl)-3-oxopropanenitrile [(R)-6c] as a JAK1 selective inhibitor. The structural design was based on the combination of tofacitinib's 7-deazapurine and 5-azaspiro?2.4]heptan-7-amine. Compound (R)-6c exhibited an IC50 value of 8.5 nM against JAK1 with a selectivity index of 48 over JAK2. To optimize (R)-6c as a lead compound, we performed in vitro ADME, hERG, kinase profiling, and pharmacokinetic tests. Mouse and rat in vivo studies verified that (R)-6c exhibited desired efficacies in CIA and AIA models.
HETEROCYCLIC TYROSINE KINASE INHIBITORS
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Page/Page column 89, (2012/05/19)
The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same. In certain embodiments, the present invention provides pharmaceutical formulations comprising provided compounds. In certain embodiments, the present invention provides a method of decreasing enzymatic activity of a Tec kinase family member. In some embodiments, such methods include contacting a Tec kinase family member with an effective amount of a Tec kinase family member inhibitor. In certain embodiments, the present invention provides a method of treating a disorder responsive to Tec kinase family inhibition in a subject in need thereof.