1354235-96-3

Basic information

• Product Name: trans-Ned 19
• Synonyms: trans-Ned 19;(1R,3S)-1-[3-[[4-(2-Fluorophenyl)-1-piperazinyl]Methyl]-4-Methoxyphenyl]-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylic Acid
• CAS NO: 1354235-96-3
• Molecular Formula: C30H30FN4O3
• Molecular Weight: 513.5826032
• Product Categories: Aromatics;Fluorescent Labels & Indicators;Heterocycles;Indole Derivatives;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Heterocycles, Indole Derivatives, Inhibitors, Fluorescent Labels & Indicators, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1354235-96-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Methanol
• CAS DataBase Reference: trans-Ned 19(CAS DataBase Reference)
• NIST Chemistry Reference: trans-Ned 19(1354235-96-3)
• EPA Substance Registry System: trans-Ned 19(1354235-96-3)

Safety Data

• Hazardous Substances Data: 1354235-96-3(Hazardous Substances Data)

Usage

Description

trans-Ned 19 is a potent and cell-permeable nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist, characterized by its ability to inhibit NAADP-mediated Ca2+ release and [32P]NAADP binding with high affinity. It is a yellow solid and can be utilized as a chemical probe due to its fluorescent properties, which allow it to label NAADP receptors in intact cells.

Uses

Used in Research Applications:
trans-Ned 19 is used as a chemical probe for studying the role of NAADP receptors in cellular processes, particularly those involving Ca2+ release. Its high affinity for NAADP receptors makes it a valuable tool for investigating the underlying mechanisms of various biological functions and potential therapeutic targets.
Used in Pharmaceutical Development:
In the pharmaceutical industry, trans-Ned 19 can be used as a starting point for the development of new drugs targeting NAADP receptors. Its potent antagonistic properties and ability to fluorescently label receptors make it a promising candidate for the creation of novel therapeutics aimed at treating conditions related to Ca2+ signaling dysregulation.
Used in Diagnostic Applications:
Due to its fluorescent labeling capabilities, trans-Ned 19 can be employed in the development of diagnostic tools and techniques for detecting and monitoring the presence and activity of NAADP receptors in various biological samples. This can be particularly useful in the early detection and diagnosis of diseases associated with altered Ca2+ signaling.