1354647-68-9

Basic information

• Product Name: ethyl 2-(1H-benzimidazol-2-yl)-3-(2-chlorophenyl)prop-2-enoate
• CAS NO: 1354647-68-9
• Molecular Weight: 326.782
• Mol File: 1354647-68-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-(1H-benzimidazol-2-yl)-3-(2-chlorophenyl)prop-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(1H-benzimidazol-2-yl)-3-(2-chlorophenyl)prop-2-enoate(1354647-68-9)
• EPA Substance Registry System: ethyl 2-(1H-benzimidazol-2-yl)-3-(2-chlorophenyl)prop-2-enoate(1354647-68-9)

Safety Data

• Hazardous Substances Data: 1354647-68-9(Hazardous Substances Data)

Upstream product

• 13570-08-6 (1H-benzimidazol-2-yl)acetic acid 
• 14741-71-0 ethyl (1H-benzimidazol-2-yl)acetate 
• 89-98-5 2-chloro-benzaldehyde 

Relevant articles and documents

New synthesis of 2-benzimidazoleacetates and study of their Knoevenagel reaction

To obtain 2-benzimidazolyl acrylate 2, a new efficient synthesis of 2-benzimidazoleacetate, involving esterification of 2-benzimidazole acetic acid at low temperature as the crucial step, was developed. The generality and efficiency of the process was illustrated by the high-yield synthesis of methyl, ethyl, i-propyl, and n-butyl 2-benzimidazoleacetate. The Knoevenagel reaction of 2-benzimidazoleacetate with aromatic aldehydes was studied. It was found that only in the presence of a catalytic amount of morpholine could the Knoevenagel reaction proceed to give the expected 3-aryl-2-benzimidazolyl acrylate. A mechanism for the morpholinecatalyzed reaction is suggested. Springer Science+Business Media B.V. 2011.