1354717-81-9Relevant articles and documents
PHYSIOLOGICALLY ACTIVE BIS-DIALKYLAMIDES OF PHOSPHORYL-SUBSTITUTED 1,4-DICARBOXYLIC ACIDS AND METHOD FOR PRODUCING SAME
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Paragraph 0020; 0025, (2013/11/19)
To produce physiologically active bis-dialkylamides of phosphorylated 1,4-dicarboxylic acids of formula (I) wherein each R can be straight or branched alkyl, unsubstituted or substituted phenyl, wherein substituents of the phenyl group can be from 1 to 5 halogen atoms, from 1 to 5 lower alkyl groups, from 1 to 5 lower alkoxy groups, from 1 to 5 dialkylamino groups; R' can be straight or branched alkyl; Y is a direct bond or a methylene group, a mixture of the corresponding phosphorylated 1,4-dicarboxylic acids is heated with hexaalkyl triamidophosphites of general formula (R'2N)3P in an organic solvent within a temperature range from 20 to 80°C until the reaction is complete followed by separation and purification. The compounds of general formula (I) thereby produced possess neuroprotective properties and can be used in medicine.