1354800-30-8

Basic information

• Product Name: N-(4-chlorobenzylidene)-5-(1-(4-isobutylphenyl)ethyl)-1,3,4-thiadiazol-2-amine
• CAS NO: 1354800-30-8
• Molecular Weight: 383.945
• Mol File: 1354800-30-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-chlorobenzylidene)-5-(1-(4-isobutylphenyl)ethyl)-1,3,4-thiadiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorobenzylidene)-5-(1-(4-isobutylphenyl)ethyl)-1,3,4-thiadiazol-2-amine(1354800-30-8)
• EPA Substance Registry System: N-(4-chlorobenzylidene)-5-(1-(4-isobutylphenyl)ethyl)-1,3,4-thiadiazol-2-amine(1354800-30-8)

Safety Data

• Hazardous Substances Data: 1354800-30-8(Hazardous Substances Data)

Upstream product

• 306963-81-5 2-(2-(4-isobutylphenyl)propanoyl)hydrazinecarbothioamide 
• 127222-69-9 ibuprofen hydrazide 
• 15687-27-1 ibuprofen 
• 41283-72-1 ibuprofen ethyl ester 
• 471254-62-3 2-amino-5-(1-(4-isobutylphenyl)ethyl)-1,3,4-thiadiazole 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1354800-41-1 C₂₂H₂₃ClN₄S₂ 

Relevant articles and documents

Synthesis and evaluation of anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation properties of new 2-(4-isobutylphenyl)propanoic acid derivatives

Synthesis and pharmacological evaluation of various 2-(4-isobutylphenyl) propanoic acid derivatives containing 1,3,4-thiadiazole and thiadiazolo[3,2-a] [1,3,5]triazine-5-thione nucleus is reported here. The structures of new compounds are supported by IR, 1H & 13C NMR data. These compounds were tested in vivo for their anti-inflammatory activity. The compounds which showed activity comparable to the standard drug ibuprofen were screened for their analgesic, ulcerogenic and lipid peroxidation activities. The compounds, which showed less ulcerogenic action, also showed reduced malondialdehyde production (MDA). Compound 4i and 5f showed 89.50 and 88.88% of inhibition in paw edema, 69.80 and 66.25% protection against acetic acid-induced writhings and 0.7 and 0.65 of severity index, respectively, compared to 90.12, 72.50 and 1.95 values of ibuprofen.