1355372-11-0

Basic information

• Product Name: (Z)-4-chloro-N-(2-(ethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2-methyl-1H-pyrrole-3-carboxamide
• CAS NO: 1355372-11-0
• Molecular Weight: 390.845
• Mol File: 1355372-11-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-4-chloro-N-(2-(ethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2-methyl-1H-pyrrole-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-4-chloro-N-(2-(ethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2-methyl-1H-pyrrole-3-carboxamide(1355372-11-0)
• EPA Substance Registry System: (Z)-4-chloro-N-(2-(ethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2-methyl-1H-pyrrole-3-carboxamide(1355372-11-0)

Safety Data

• Hazardous Substances Data: 1355372-11-0(Hazardous Substances Data)

Upstream product

• 936-12-9 2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 1161114-83-5 4-chloro-5-formyl-2-methyl-1H-pyrrole-3-carboxylic acid 
• 56341-41-4 5-fluoroindol-2(3H)-one 
• 1355371-97-9 C₁₁H₁₆ClN₃O₂ 
• 57061-48-0 ethyl 5-formyl-2-methyl-1H-pyrrole-3-carboxylate 
• 38367-46-3 ethyl 4-chloro-5-formyl-2-methyl-1H-pyrrole-3-carboxylate 

Relevant articles and documents

Synthesis and biological evaluation of 3-substituted-indolin-2-one derivatives containing chloropyrrole moieties

Eighteen novel 3-substituted-indolin-2-ones containing chloropyrroles were synthesized and their biological activities were evaluated. The presence of a chlorine atom on the pyrrole ring was crucial to reduce cardiotoxicity. The presence of a 2-(ethylamino) ethylcarbamoyl group as a substituent at the C-4' position of the pyrrole enhanced the antitumor activities notably. IC 50 values as low as 0.32, 0.67, 1.19 and 1.22 μM were achieved against non-small cell lung cancer (A549), oral epithelial (KB), melanoma (K111) and large cell lung cancer cell lines (NCI-H460), respectively.