1356006-94-4Relevant articles and documents
Preformed selenoesters enable rapid native chemical ligation at intractable sites
Durek, Thomas,Alewood, Paul F.
supporting information; experimental part, p. 12042 - 12045 (2012/02/14)
Going pro: The first facile Pro-Cys ligation using a preformed prolyl selenoester is reported (see scheme; P=peptide). In a comparative study of peptide selenoesters in native chemical ligation peptide α-selenoesters are shown to be superior acyl donors and result in rate enhancements of at least two orders of magnitude when compared to the well-established peptide α-thioesters. This method permits rapid chemical ligation even at previously intractable sites, such as Pro-Cys. Copyright
