1356058-94-0Relevant articles and documents
Synthesis and biological evaluation of spiro-δ-lactones as inhibitors of 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2)
Xu, Kuiying,Wetzel, Marie,Hartmann, Rolf W.,Marchais-Oberwinkler, Sandrine
, p. 406 - 421 (2012/06/18)
17β-Hydroxysteroid dehydrogenase type 2 (17β-HSD2) catalyzes the oxidation of the potent estradiol (E2) to the less active estrogen estrone (E1). Inhibitors of this enzyme should maintain the local level of E2 in bone tissue when the E2 concentration in t