135622-82-1

Basic information

• Product Name: ADP-RIBOSYLCYCLASE
• Synonyms: ADP-RIBOSYLCYCLASE;Adenosine diphosphoribose cyclase from Aplysia californica
• CAS NO: 135622-82-1
• Molecular Weight: 0
• Mol File: 135622-82-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: ADP-RIBOSYLCYCLASE(CAS DataBase Reference)
• NIST Chemistry Reference: ADP-RIBOSYLCYCLASE(135622-82-1)
• EPA Substance Registry System: ADP-RIBOSYLCYCLASE(135622-82-1)

Safety Data

• WGK Germany: 2
• Hazardous Substances Data: 135622-82-1(Hazardous Substances Data)

Usage

Description

ADP-RIBOSYLCYCLASE, also known as ADP-ribosyl cyclase, is an enzyme that plays a crucial role in the production of cyclic ADP-ribose (cADPR), a calcium signaling second messenger. It is involved in various cellular processes, including calcium mobilization, signal transduction, and regulation of cellular functions. The enzyme catalyzes the conversion of NAD+ into cADPR and ADP-ribose, which are essential for intracellular calcium release and subsequent cellular responses.
Source:
ADP-RIBOSYLCYCLASE is found in various organisms, including humans, and is involved in the regulation of intracellular calcium levels.
Production Methods:
The enzyme is produced through the natural synthesis within cells, where it is involved in the conversion of NAD+ to cADPR and ADP-ribose.

Uses

Used in Research Applications:
ADP-RIBOSYLCYCLASE is used as a research tool for studying calcium signaling pathways, which are essential for various cellular processes and functions. It has been employed in the investigation of morphine antinociception and tolerance, providing insights into the underlying mechanisms of pain relief and the development of drug tolerance.
Used in Pharmaceutical Industry:
ADP-RIBOSYLCYCLASE is used as a target for the development of new drugs and therapies related to calcium signaling and related cellular processes. Understanding the role of this enzyme in cellular functions can lead to the development of novel treatments for various diseases and conditions, including those involving calcium dysregulation.
Used in Diagnostic Applications:
ADP-RIBOSYLCYCLASE can be used as a biomarker for the assessment of calcium signaling dysregulation in various diseases. Measuring the activity or expression of this enzyme can provide valuable information about the status of calcium signaling pathways and help in the diagnosis and monitoring of related conditions.

Biochem/physiol Actions

ADP-ribosylcyclase is an intracellular calcium regulator that cyclizes NAD into cADPR. It is thought that the majority of ADP-ribosylcyclase activity in the brain is linked to CD38. Nicotinamide is a known inhibitor of CD38 ADP-ribosylcyclase activity .

Related news

[30] Large-scale purification of Aplysia ADP-RIBOSYLCYCLASE (cas 135622-82-1) and measurement of its activity by fluorimetric assay08/14/2019

Publisher SummaryCyclic ADP-ribose (cADPR) is a Ca2+-mobilizing cyclic nucleotide that functions as an endogenous modulator of the Ca2+-induced Ca2+ release mechanism in cells. Its synthesizing enzyme, ADP-ribosylcyclase, is widely distributed among animal tissues and is particularly abundant in...detailed