1356600-78-6Relevant articles and documents
Biotin-guided anticancer drug delivery with acidity-triggered drug release
Park, Soyeon,Kim, Eunjin,Kim, Won Young,Kang, Chulhun,Kim, Jong Seung
, p. 9343 - 9345 (2015)
A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.
HETEROCYCLIC COMPOUND
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Paragraph 0535, (2015/03/03)
The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.