1356959-88-0Relevant articles and documents
Ligand-based design of a potent and selective inhibitor of cytochrome P450 2C19
Foti, Robert S.,Rock, Dan A.,Han, Xiaogang,Flowers, Robert A.,Wienkers, Larry C.,Wahlstrom, Jan L.
, p. 1205 - 1214 (2012)
A series of omeprazole-based analogues was synthesized and assessed for inhibitory activity against CYP2C19. The data was used to build a CYP2C19 inhibition pharmacophore model for the series. The model was employed to design additional analogues with inh