1357013-19-4Relevant articles and documents
Regio- and Stereospecific Copper-Catalyzed Substitution Reaction of Propargylic Ammonium Salts with Aryl Grignard Reagents
Guisán-Ceinos, Manuel,Martín-Heras, Victor,Tortosa, Mariola
supporting information, p. 8448 - 8451 (2017/07/06)
We have developed a copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents. The reaction is stereospecific and α-regioselective and proceeds with exceptional functional group tolerance. Conveniently, a stable, inexpensive, and commercially available copper salt is used and no added ligand is required.