135705-03-2Relevant articles and documents
ANXIOLYTIC ACTIVITY OF DERIVATIVES OF 1-(2-PYRIMIDINYL)PIPERAZINE
Komissarov, I. V.,Kharin, N. A.,Voshula, V. N.,Tolkunov, S. V.,Kibal'nyi, A. V.,et al.
, p. 193 - 196 (2007/10/02)
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135705-03-2
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Basic information
- Product Name: 1-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)-2-butynyl)-2,5-pyrrolidinedione
- Synonyms: 1-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)-2-butynyl)-2,5-pyrrolidinedione
- CAS NO:135705-03-2
- Molecular Formula: C16H19N5O2
- Molecular Weight: 313.35
- EINECS: N/A
- Product Categories: N/A
- Mol File: 135705-03-2.mol
- Article Data: 1
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 582.4°Cat760mmHg
- Flash Point: 306°C
- Appearance: /
- Density: 1.295g/cm3
- Vapor Pressure: 1.49E-13mmHg at 25°C
- Refractive Index: 1.603
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 1-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)-2-butynyl)-2,5-pyrrolidinedione(CAS DataBase Reference)
- NIST Chemistry Reference: 1-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)-2-butynyl)-2,5-pyrrolidinedione(135705-03-2)
- EPA Substance Registry System: 1-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)-2-butynyl)-2,5-pyrrolidinedione(135705-03-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 135705-03-2(Hazardous Substances Data)
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135705-03-2 Usage
Description
1-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)-2-butynyl)-2,5-pyrrolidinedione, also known as TPA-023, is a chemical compound that functions as a potent and selective positive allosteric modulator of the GABAA receptor subtype. It acts as an agonist at the benzodiazepine binding site on the GABAA receptor, which results in increased GABAergic neurotransmission and anxiolytic effects. TPA-023 has demonstrated potential for treating anxiety and other psychiatric disorders, presenting a more favorable pharmacological profile and fewer side effects compared to traditional benzodiazepines. Its specificity in targeting certain GABAA receptor subtypes suggests a more tailored and effective treatment option for conditions related to dysfunctional GABAergic neurotransmission.Uses
Used in Pharmaceutical Industry:TPA-023 is used as a therapeutic agent for the treatment of anxiety and other psychiatric disorders due to its anxiolytic effects and enhanced GABAergic neurotransmission. Its selective action on specific GABAA receptor subtypes and fewer side effects compared to traditional benzodiazepines make it a promising candidate for more effective and safer treatments.
Used in Research and Development:
TPA-023 is utilized as a research tool for studying the role of GABAA receptor subtypes in anxiety and other psychiatric disorders. Its selective modulation of these receptors can provide valuable insights into the underlying mechanisms of these conditions and contribute to the development of novel treatment strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 135705-03-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,7,0 and 5 respectively; the second part has 2 digits, 0 and 3 respectively.Calculate Digit Verification of CAS Registry Number 135705-03:
(8*1)+(7*3)+(6*5)+(5*7)+(4*0)+(3*5)+(2*0)+(1*3)=112
112 % 10 = 2
So 135705-03-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H19N5O2/c22-14-4-5-15(23)21(14)9-2-1-8-19-10-12-20(13-11-19)16-17-6-3-7-18-16/h3,6-7H,4-5,8-13H2
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1-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)-2-butynyl)-2,5-pyrrolidinedione
