1357059-00-7 Usage
Description
(E)-5-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-2,4-dimethylbenzenesulfonic acid is a synthetic compound characterized by its diazenyl group attached to a sulfonic acid and two methylbenzene rings. It is known for its vibrant and stable color properties, making it a popular choice for dyeing and printing processes. Its solubility in water allows for a wide range of applications, while its potential to cause skin and eye irritation necessitates careful handling and adherence to safety precautions.
Uses
Used in Dye and Pigment Production:
(E)-5-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-2,4-dimethylbenzenesulfonic acid is used as a colorant in the production of dyes and pigments, particularly for its vibrant and stable color properties.
Used in Food Industry:
In the food industry, (E)-5-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-2,4-dimethylbenzenesulfonic acid is used as an additive for coloring various products, capitalizing on its ability to provide stable and vibrant hues.
Used in Textile Industry:
(E)-5-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-2,4-dimethylbenzenesulfonic acid is used as a dye in the textile industry, where its water solubility and colorfastness make it suitable for dyeing fabrics.
Used in Cosmetics Industry:
Within the cosmetics industry, (E)-5-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-2,4-dimethylbenzenesulfonic acid is used as a colorant for various cosmetic products, ensuring that they maintain their appearance and appeal over time.
Check Digit Verification of cas no
The CAS Registry Mumber 1357059-00-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,7,0,5 and 9 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1357059-00:
(9*1)+(8*3)+(7*5)+(6*7)+(5*0)+(4*5)+(3*9)+(2*0)+(1*0)=157
157 % 10 = 7
So 1357059-00-7 is a valid CAS Registry Number.
1357059-00-7Relevant articles and documents
Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains
Zhang, Guangtao,Plotnikov, Alexander N.,Rusinova, Elena,Shen, Tong,Morohashi, Keita,Joshua, Jennifer,Zeng, Lei,Mujtaba, Shiraz,Ohlmeyer, Michael,Zhou, Ming-Ming
, p. 9251 - 9264 (2014/01/06)
BRD4, characterized by two acetyl-lysine binding bromodomains and an extra-terminal (ET) domain, is a key chromatin organizer that directs gene activation in chromatin through transcription factor recruitment, enhancer assembly, and pause release of the RNA polymerase II complex for transcription elongation. BRD4 has been recently validated as a new epigenetic drug target for cancer and inflammation. Our current knowledge of the functional differences of the two bromodomains of BRD4, however, is limited and is hindered by the lack of selective inhibitors. Here, we report our structure-guided development of diazobenzene-based small-molecule inhibitors for the BRD4 bromodomains that have over 90% sequence identity at the acetyl-lysine binding site. Our lead compound, MS436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated Ki of 30-50 nM), with preference for the first bromodomain over the second. We demonstrated that MS436 effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages. MS436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression.
