1357298-75-9

Basic information

• Product Name: trans-4'-(2-aminocyclopropyl)-(1,1'-biphenyl)-3-ol hydrochloride
• CAS NO: 1357298-75-9
• Molecular Weight: 261.751
• Mol File: 1357298-75-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: trans-4'-(2-aminocyclopropyl)-(1,1'-biphenyl)-3-ol hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: trans-4'-(2-aminocyclopropyl)-(1,1'-biphenyl)-3-ol hydrochloride(1357298-75-9)
• EPA Substance Registry System: trans-4'-(2-aminocyclopropyl)-(1,1'-biphenyl)-3-ol hydrochloride(1357298-75-9)

Safety Data

• Hazardous Substances Data: 1357298-75-9(Hazardous Substances Data)

Upstream product

• 1228092-84-9 (1R,2RS)-(-)-2-(4-bromophenyl)cyclopropyl-1-amine hydrochloride 
• 1418287-95-2 (±)-trans-O-tert-butyl-N-(2-(4-bromophenyl)cyclopropyl)carbamate 

Relevant articles and documents

C-H activation enables a rapid structure-activity relationship study of arylcyclopropyl amines for potent and selective LSD1 inhibitors

We describe the structure-activity relationship of various arylcyclopropylamines (ACPAs), which are potent LSD1 inhibitors. More than 45 ACPAs were synthesized rapidly by an unconventional method that we have recently developed, consisting of a C-H borylation and cross-coupling sequence starting from cyclopropylamine. We also generated NCD38 derivatives, which are known as LSD1 selective inhibitors, and discovered a more effective inhibitor compared to the original NCD38.