135733-31-2

Basic information

• Product Name: 4-(hydroxymethyl)-3-phenylfuroxan
• Synonyms: 4-(hydroxymethyl)-3-phenylfuroxan
• CAS NO: 135733-31-2
• Molecular Weight: 192.174
• Mol File: 135733-31-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-(hydroxymethyl)-3-phenylfuroxan(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(hydroxymethyl)-3-phenylfuroxan(135733-31-2)
• EPA Substance Registry System: 4-(hydroxymethyl)-3-phenylfuroxan(135733-31-2)

Safety Data

• Hazardous Substances Data: 135733-31-2(Hazardous Substances Data)

Upstream product

• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 104-54-1 3-Phenylpropenol 
• 135733-30-1 3-(hydroxymethyl)-4-phenylfuroxan 

Downstream Products

• 1380783-68-5 C₂₀H₂₂N₄O₆S 
• 1380783-74-3 C₁₅H₁₂N₂O₃ 
• 1380783-62-9 4-(3-phenylfuroxan-4-yl-methoxy)benzenesulfonamide 
• 1380783-59-4 4-bromo-methyl-3-phenylfuroxan 
• 118898-87-6 2-phenyl-2-hydroxyiminoacetonitrile oxide 
• 125520-55-0 3-carboxy-4-phenyl-1,2,5-oxadiazole 2-oxide 
• 86340-05-8 3-benzoyl-5-phenylisoxazole oxime 
• 3672-49-9 phenyl(5-phenyl-1,2-oxazol-3-yl)methanone 
• 135733-30-1 3-(hydroxymethyl)-4-phenylfuroxan 
• 135733-35-6 3-phenyl-4-furoxancarbaldehyde 
• 125520-61-8 3-phenyl-4-furoxancarboxylic acid 

Relevant articles and documents

Synthesis of Furoxans (1,2,5-oxadiazole 2-oxides) from Styrenes and Nitrosonium Tetrafluoroborate in Non-Acidic Media and Mechanistic Study

Diverse furoxans (1,2,5-oxadiazole 2-oxides) were synthesized from the corresponding styrenes using nitrosonium tetrafluoroborate as the nitrosation reagent in pyridine (basic media) or dichloromethane (neutral media). Acid-sensitive functional groups were tolerated under these conditions. The probable reaction mechanism was elucidated. The experimental results support an ionic reaction pathway in contrast to the conventional acidic conditions with a radical mechanism.

Synthesis of oxadiazole-2-oxide analogues as potential antischistosomal agents

The synthesis of several 1,2,5-oxadiazole-2-oxide (Furoxan) analogues is described herein. These compounds were prepared in an effort to probe the SAR around the phenyl substituent and oxadiazole core for our studies toward thioredoxin-glutathione reductase (TGR) inhibition and antischistosomal activity.

Pharmacochemistry of the furoxan ring: Recent developments

In the present work recent results obtained in the pharmacochemistry of the furoxan system are reported. In particular, after a brief description of the salient points of the furoxan chemistry, the synthesis and the properties of a series of Nifedipine and Prazosin analogues, containing this heterocyclic system, are described. Since we observed that a few furoxan derivatives are able to elicit both a dose-dependent rise in platelet cGMP levels and to promote a dose-dependent inhibition of AA-induced [Ca++] rise, and that many substituted furoxans show potent vasodilating and antiaggregatory activity, the possibility of using the furoxan system as a lead in the design of new vasodilators is also discussed.