135748-34-4

Basic information

• Product Name: 2-Chloro-4,5-difluorobenzonitrile
• Synonyms: 2-CHLORO-4,5-DIFLUOROBENZONITRILE;2-Chloro-4,5-difluorobenzonitrile 98%;2-Chloro-4,5-difluorobenzonitrile98%
• CAS NO: 135748-34-4
• Molecular Formula: C₇H₂ClF₂N
• Molecular Weight: 173.55
• Product Categories: Nitrile
• Mol File: 135748-34-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 33-36℃
• Boiling Point: 231.5 °C at 760 mmHg
• Flash Point: 93.8 °C
• Appearance: 26-36/37/39
• Density: 1.43g/cm³
• Vapor Pressure: 0.0622mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Chloro-4,5-difluorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4,5-difluorobenzonitrile(135748-34-4)
• EPA Substance Registry System: 2-Chloro-4,5-difluorobenzonitrile(135748-34-4)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-39
• RIDADR: 3276
• HazardClass: 6.1
• Hazardous Substances Data: 135748-34-4(Hazardous Substances Data)

Usage

General Description

2-Chloro-4,5-difluorobenzonitrile, also known as DFB, is a chemical compound with the molecular formula C7H2ClF2N. It is a white solid with a melting point of 87-90°C and a boiling point of 184-186°C. DFB is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, due to its versatile reactivity and ability to undergo a wide range of chemical reactions. It is also utilized as a building block in the production of dyes, pigments, and specialty chemicals. However, it is important to handle 2-Chloro-4,5-difluorobenzonitrile with caution, as it is classified as a hazardous substance and may cause irritation to the skin, eyes, and respiratory system upon exposure.

InChI:InChI=1/C7H2ClF2N/c8-5-2-7(10)6(9)1-4(5)3-11/h1-2H

Upstream product

• 296274-32-3 2-chloro-4,5-difluorobenzamide 
• 128593-93-1 2,4-dichloro-5-fluoro-benzonitrile 
• 3115-68-2 tetrabutyl phosphonium bromide 

Relevant articles and documents

CYCLIC AMINE COMPOUND

A compound represented by the formula (I) or a salt thereof: (I) wherein the ring A represents a 5- to 8-membered ring which may have additional substituent besides R6, R7 and R8; R1 represents an electron-attracting group; R2, R3, R4 and R5 independently represent a hydrogen atom, a halogen atom, a group attached through a carbon atom, a group attached through a nitrogen atom, a group attached through an oxygen group, or a group attached through a sulfur atom; R6 represents a halogen atom, a group attached through a carbon atom, a group attached through a nitrogen atom, a group attached through an oxygen group, or a group attached through a sulfur atom, and R7 represents a cyano group, a nitro group, an acyl group which may have a substituent, a carboxyl group which may be esterified or amidated, or a hydrocarbon group which may have a substituent, or R6 and R7 together with a carbon atom to which they are attached may form a ring which may have a substituent; and R8 represents a hydrogen atom, a halogen atom, a group attached through a carbon atom, a group attached through an oxygen atom, or a group attached through a sulfur atom. The compound or salt has an excellent androgen receptor modulating effect, and is useful for the prevention/treatment of hypogonadism, partial androgen deficiency in aging male, decline in physical strength, cachexia, osteoporosis and the like.

Processes for producing 5-fluorobenzoic acids and their intermediates

A process for producing a 5-fluorobenzoic acid of the formula (V), which comprises trichloromethylating a fluorobenzene of the formula (I) to obtain a 5-fluorobenzotrichloride of the formula (II), then reacting it with aqueous ammonia to obtain a 5-fluorobenzonitrile of the formula (III), reacting it with a fluorinating agent to obtain a 5-fluorobenzonitrile of the formula (IV) and hydrolyzing it: STR1 wherein each of X1, X3, Y1 and Y3 is a halogen atom, and each of X2 and Y2 is hydrogen or a halogen atom.