135754-82-4

Basic information

• Product Name: 3,N-DIMETHYL-N-METHOXYBENZAMIDE
• Synonyms: 3,N-DIMETHYL-N-METHOXYBENZAMIDE;N-Methoxy-N,3-dimethylbenzamide
• CAS NO: 135754-82-4
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Mol File: 135754-82-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 320.1°C at 760 mmHg
• Flash Point: 147.4°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 0.000324mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: 3,N-DIMETHYL-N-METHOXYBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,N-DIMETHYL-N-METHOXYBENZAMIDE(135754-82-4)
• EPA Substance Registry System: 3,N-DIMETHYL-N-METHOXYBENZAMIDE(135754-82-4)

Safety Data

• Hazardous Substances Data: 135754-82-4(Hazardous Substances Data)

Usage

Description

3,N-DIMETHYL-N-METHOXYBENZAMIDE, also known as N-Methoxy-N,3-dimethylbenzamide, is an organic compound with the molecular formula C10H13NO2. It is a derivative of benzamide, featuring a methoxy group and two methyl groups attached to the benzene ring. 3,N-DIMETHYL-N-METHOXYBENZAMIDE is known for its potential applications in various chemical and pharmaceutical processes due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
3,N-DIMETHYL-N-METHOXYBENZAMIDE is used as an intermediate in the synthesis of various pharmaceutical compounds for its ability to be modified and incorporated into more complex molecular structures. Its unique structural features make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
3,N-DIMETHYL-N-METHOXYBENZAMIDE is used as a reactant in catalytic reactions for the synthesis of 4H-3,1-benzoxazin-4-ones. These benzoxazinones are important compounds with a wide range of applications, including their use as pharmaceuticals, agrochemicals, and dyes. The use of 3,N-DIMETHYL-N-METHOXYBENZAMIDE in this process highlights its versatility and utility in the synthesis of valuable chemical products.

InChI:InChI=1/C10H13NO2/c1-8-5-4-6-9(7-8)10(12)11(2)13-3/h4-7H,1-3H3

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 1711-06-4 3-Methylbenzoyl chloride 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 591-17-3 meta-bromotoluene 
• 13939-06-5 molybdenum hexacarbonyl 
• 15226-74-1 dicobalt octacarbonyl 
• 14040-11-0 tungsten hexacarbonyl 
• 587-03-1 3-methylbenzyl alcohol 
• 99-04-7 m-Toluic acid 

Downstream Products

• 216529-53-2 1-(3-methylphenyl)-2-(pyridin-4-yl)ethanone 
• 210967-20-7 (4-aminophenyl)(3-methylphenyl)methanone 
• 210966-71-5 {4-[(2-nitrophenyl)amino]phenyl}(3-methylphenyl)methanone 
• 844879-24-9 (3-bromophenyl)-m-tolylmethanone 
• 620-22-4 3-Methylbenzonitrile 
• 54095-43-1 1-(3-methylphenyl)-3-phenylpropan-1-one 
• 620-23-5 m-tolyl aldehyde 
• 95606-81-8 2-phenyl-1-(m-tolyl)ethan-1-one 
• 74786-81-5 m-methyl-N-methylbenzamide 
• 26954-33-6 1-(3-methylphenyl)pent-4-en-1-one 
• 117039-85-7 6-methyl-2-phenyl-4H-benzo[d][1,3]oxazin-4-one 
• 50562-05-5 2,2-difluoro-1-(3-methylphenyl)ethan-1-one 
• 51772-30-6 3'-Methylpropiophenone 
• 1613406-81-7 3‐(m‐tolyl)isobenzofuran‐1(3H)‐one 

Relevant articles and documents

Rhoda-Electrocatalyzed Bimetallic C?H Oxygenation by Weak O-Coordination

Rhodium-electrocatalyzed arene C?H oxygenation by weakly O-coordinating amides and ketones have been established by bimetallic electrocatalysis. Likewise, diverse dihydrooxazinones were selectively accessed by the judicious choice of current, enabling twofold C?H functionalization. Detailed mechanistic studies by experiment, mass spectroscopy and cyclovoltammetric analysis provided support for an unprecedented electrooxidation-induced C?H activation by a bimetallic rhodium catalysis manifold.

Synthesis of Difluoromethyl Ketones from Weinreb Amides, and Tandem Addition/Cyclization of o-Alkynylaryl Weinreb Amides

[Difluoro(phenylsulfanyl)methyl]trimethylsilane (PhSCF2SiMe3) underwent a fluoride-induced nucleophilic addition to the carbonyl group of Weinreb amides to provide the corresponding difluoro(phenylsulfanyl)methyl ketones. These were

One-Pot Direct Synthesis of Weinreb Amides from Aryl and Hetero Aryl Halides Using Co 2(CO) 8 as an Effective CO Source under Conventional Thermal Heating

A successful protocol for the synthesis of Weinreb amides directly from aryl halides via aminocarbonylation with N,O-dimethyl hydroxylamine using Co2(CO)8 as an in situ CO source has been demonstrated. The effects of various reaction parameters such as temperature, base, and CO source have also been investigated and optimized. GRAPHICAL ABSTRACT.