1357592-87-0Relevant articles and documents
Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket
Yoshikawa, Masato,Hitaka, Takenori,Hasui, Tomoaki,Fushimi, Makoto,Kunitomo, Jun,Kokubo, Hironori,Oki, Hideyuki,Nakashima, Kosuke,Taniguchi, Takahiko
, p. 3447 - 3455 (2016/07/21)
Utilizing structure-based drug design techniques, we designed and synthesized phosphodiesterase 10A (PDE10A) inhibitors based on pyridazin-4(1H)-one. These compounds can interact with Tyr683 in the PDE10A selectivity pocket. Pyridazin-4(1H)-one derivative