13576-51-7

Basic information

• Product Name: 5-(4-chlorophenyl)oxazol-2-amine
• Synonyms: 5-(4-chlorophenyl)oxazol-2-amine;5-(4-Chlorophenyl)-2-oxazolamine
• CAS NO: 13576-51-7
• Molecular Formula: C₉H₇ClN₂O
• Molecular Weight: 195
• Mol File: 13576-51-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 368.4 °C at 760 mmHg
• Flash Point: 176.6 °C
• Appearance: /
• Density: 1.342 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(4-chlorophenyl)oxazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorophenyl)oxazol-2-amine(13576-51-7)
• EPA Substance Registry System: 5-(4-chlorophenyl)oxazol-2-amine(13576-51-7)

Safety Data

• Hazardous Substances Data: 13576-51-7(Hazardous Substances Data)

Usage

General Description

5-(4-Chlorophenyl)oxazol-2-amine is a chemical compound with the molecular formula C9H7ClN2O. It is known for its use in the synthesis of various pharmaceutical compounds and agrochemicals. This chemical is a derivative of oxazole, which is a five-membered aromatic heterocycle containing one oxygen and one nitrogen atom. The presence of a chlorophenyl group in the molecule makes it a valuable intermediate for the production of diverse organic compounds. 5-(4-Chlorophenyl)oxazol-2-amine has potential applications in the development of new drugs and can be used as a building block for constructing complex molecular architectures with biological activity. Its properties and reactivity make it a valuable compound in the field of organic chemistry and drug discovery.

Upstream product

• 536-38-9 4-chlorobenzoylmethyl bromide 
• 918164-36-0 1-[2-(4-chlorophenyl)-2-oxoethyl]pyrimidin-2(1H)-one 
• 76758-13-9 5-p-chlorophenyl-2-triphenylmethylaminooxazole 

Relevant articles and documents

Novel and efficient synthesis of 2-aminooxazoles from pyrimidin-2(1H)-one

Stepwise conversion of pyrimidin-2(1H)-one to 2-amino-5-aryloxazoles via oxazolo[3,2-a]pyrimidinium salts is reported. The sequence involves, (i) regioselective N-alkylation of pyrimidone by phenacyl bromides, (ii) cyclization of obtained 1-(2-aryl-2-oxoethyl)pyrimidin-2(1H)-ones into oxazolo[3,2-a] pyrimidinium salts under the action of fuming sulfuric (or triflic) acid, and (iii) reaction of the obtained salts with hydrazine leading to 2-amino-5-aryloxazoles. Georg Thieme Verlag Stuttgart.

Synthesis of N-(Tosylmethyl)carbodiimides and Their Application in the Synthesis of 2-Amino-1,3-oxazoles from Aldehydes

A series of N-(tosylmethyl)carbodiimides (TosCH2N=C=NR1, 3) have been prepared from the corresponding thioureas.Carbodiimides 3 with R1 = triphenylmethyl or tert-butyl are useful synthons in a new one-step synthesis of 2-(alkylamino)-1,3-oxazoles 10 from aromatic aldehydes.Acid-induced removal of the triphenylmethyl group from 10 gives 2-amino-1,3-oxazoles (11).