1357912-51-6

Basic information

• Product Name: ((2R,3S,4S)-2-(4-fluorophenyl)-4-hydroxytetrahydrothiophen-3-yl)(phenyl)methanone
• Synonyms: ((2R,3S,4S)-2-(4-fluorophenyl)-4-hydroxytetrahydrothiophen-3-yl)(phenyl)methanone
• CAS NO: 1357912-51-6
• Molecular Weight: 302.369
• Mol File: 1357912-51-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ((2R,3S,4S)-2-(4-fluorophenyl)-4-hydroxytetrahydrothiophen-3-yl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: ((2R,3S,4S)-2-(4-fluorophenyl)-4-hydroxytetrahydrothiophen-3-yl)(phenyl)methanone(1357912-51-6)
• EPA Substance Registry System: ((2R,3S,4S)-2-(4-fluorophenyl)-4-hydroxytetrahydrothiophen-3-yl)(phenyl)methanone(1357912-51-6)

Safety Data

• Hazardous Substances Data: 1357912-51-6(Hazardous Substances Data)

Upstream product

• 40018-26-6 1,4-dithiane-2,5-diol 
• 618-41-7 Benzenesulfinic acid 
• 1608-51-1 4-fluorochalcone 

Relevant articles and documents

Enantioselective one-pot synthesis of β-sulfonyl ketones and trisubstituted tetrahydrothiophenes via β-elimination/cycloaddition sequence

A mild and efficient enantioselective one-pot synthesis of β-sulfonyl ketones and trisubstituted tetrahydrothiophenes via introducing 1,4-dithiane-2,5-diol to the simple kinetic resolution of β-sulfonyl ketones has been described herein. The one-pot reaction sequence including kinetic resolution and cascade sulfa-Michael/Aldol reaction proceeded successively to afford corresponding sulfonyl ketones and tetrahydrothiophenes with high enantioselectivities (85%–98% ee and 84%–95% ee).

Hydrogen-bond-mediated cascade reaction involving chalcones: Facile synthesis of enantioenriched trisubstituted tetrahydrothiophenes

A bifunctional squaramide catalyzed sulfa-Michael/aldol cascade reaction between 1,4-dithiane-2,5-diol and chalcones with a low catalyst loading has been developed. Trisubstituted tetrahydrothiophenes with three contiguous stereogenic centers are obtained