135902-07-7Relevant articles and documents
SUGAR-ANALOG PHOSPHORUS-CONTAINING HETEROCYCLES HAVING AN ANTI-METASTATIC ACTIVITY
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Paragraph 0133; 0134; 0135, (2016/03/04)
The use of compounds of formula (1) as defined in the description, for reducing or preventing the onset of metastases in a patient suffering from cancer. Pharmaceutical compositions for using in human or veterinary medicine, including at least one compoun
Renin Inhibitory Pentols Showing Improved Enteral Bioavailability
Kleemann, Heinz-Werner,Heitsch, Holger,Henning, Rainer,Kramer, Werner,Kocher, Walter,et al.
, p. 559 - 567 (2007/10/02)
Incorporation of a C-terminal pentahydroxy functionality led to potent, low molecular weight hydrophilic renin inhibitors lacking the P1' side chain.As these compounds are easy to synthesize and have sufficient water solubility, they were chosen for further study.Compound 33 was transported across rabbit intestinal brush border membrane vesicles and yielded a hypotensive effect in sodium-depleted rhesus monkeys which lasted for 90 min when dosed at 2 mg/kg id.