1359020-96-4Relevant articles and documents
Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones
Spicer, Julie A.,Huttunen, Kristiina M.,Miller, Christian K.,Denny, William A.,Ciccone, Annette,Browne, Kylie A.,Trapani, Joseph A.
, p. 1319 - 1336 (2012/03/26)
An aryl-substituted isobenzofuran-1(3H)-one lead compound was identified from a high throughput screen designed to find inhibitors of the lymphocyte pore-forming protein perforin. A series of analogs were then designed and prepared, exploring structure-ac