13595-17-0 Usage
Description
4-aminobicyclo(2,2,2)octane-1-carboxylic acid is an organic compound with a unique bicyclic structure and an amino group. It is a versatile building block in the synthesis of various pharmaceutical compounds and has potential applications in the development of novel drugs.
Uses
Used in Cancer Treatment:
4-aminobicyclo(2,2,2)octane-1-carboxylic acid is used as a key component in the preparation of AA-115/APG-115, a potent and orally active murine double minute 2 (MDM2) inhibitor. 4-aminobicyclo(2,2,2)octane-1-carboxylic acid is useful in cancer treatment, as it targets the MDM2 protein, which is often overexpressed in various types of cancer, leading to the inhibition of tumor growth.
Used in Structure Activity Optimization:
4-aminobicyclo(2,2,2)octane-1-carboxylic acid is used as a building block in the structure-activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines. These compounds act as Jak1 kinase inhibitors, which are important targets for the treatment of various diseases, including cancer and autoimmune disorders.
Used in the Preparation of PI3Kγ Inhibitors:
4-aminobicyclo(2,2,2)octane-1-carboxylic acid is also useful in the preparation of PI3Kγ inhibitors. PI3Kγ (phosphoinositide 3-kinase gamma) is an enzyme that plays a role in the immune response and has been implicated in the development of various diseases, including cancer and inflammatory disorders. Inhibiting PI3Kγ activity can potentially lead to the development of new therapeutic strategies for these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 13595-17-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,5,9 and 5 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 13595-17:
(7*1)+(6*3)+(5*5)+(4*9)+(3*5)+(2*1)+(1*7)=110
110 % 10 = 0
So 13595-17-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H15NO2/c10-9-4-1-8(2-5-9,3-6-9)7(11)12/h1-6,10H2,(H,11,12)
13595-17-0Relevant articles and documents
ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF
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, (2021/10/30)
The invention provides anti-VISTA antibody drug conjugates which may be used for targeted delivery of anti-inflammatory agents such as steroids to immune cells, e.g., myeloid cells. The invention also provides methods of using anti-VISTA antibody drug conjugates in the treatment of inflammatory and/or autoimmune conditions and/or for alleviating the toxicity of anti-inflammatory agents such as steroids.
