135970-08-0

Basic information

• Product Name: N-acetyl-(7,7-dimethylnorborn-2R-yl)-(R)-alanine
• CAS NO: 135970-08-0
• Molecular Weight: 253.342
• Mol File: 135970-08-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-acetyl-(7,7-dimethylnorborn-2R-yl)-(R)-alanine(CAS DataBase Reference)
• NIST Chemistry Reference: N-acetyl-(7,7-dimethylnorborn-2R-yl)-(R)-alanine(135970-08-0)
• EPA Substance Registry System: N-acetyl-(7,7-dimethylnorborn-2R-yl)-(R)-alanine(135970-08-0)

Safety Data

• Hazardous Substances Data: 135970-08-0(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 135897-14-2 (7,7-dimethylnorborn-2R-yl)-(R,S)-alanine hydrochloride 
• 64439-31-2 (1R)-endo-(+)-fenchylalcohol 
• 116724-26-6 α-fenchene 
• 135897-12-0 (7,7-dimethylnorborn-2R-yl)-acetaldehyde 
• 135897-10-8 7,7-dimethyl-2-formylmethylene norbornane 
• 135897-13-1 (7,7-dimethylnorborn-2R-yl)-(R,S)-2-amino propionitrile 
• 135897-18-6 N-acetyl-(7,7-dimethylnorborn-2R-yl)-(R,S)-alanine 

Downstream Products

• 135897-15-3 (7,7-dimethylnorborn-2R-yl)-(S)-alanine 

Relevant articles and documents

An Improved Synthesis of (S)-Aspartyl-(7,7-Dimethylnorborn-2R-yl)-(S)-Alanine Methyl Esters, A New High Intensity Artificial Sweetener

(S)-Aspartyl-(7,7-dimethylnorborn-2R-yl)-(S)-alanine methyl ester (1) was synthesized in nine steps from (+)-α-fenchyl alcohol (3) as a chiral synthon.Crucial steps for controlling the side-chain stereochemistry of 1, required for the manifestation of sweentness, were the catalytic hydroformylation of the olefin 4 and the enzymatic resolution of the racemic amino acid 9 using acylase I. Key Words: sweetener, (+)-α-fenchyl alcohol, (+)-α-fenchene, catalytic hydroformylation, enzymatic resolution.