1359976-55-8

Basic information

• Product Name: 3-{2-[4-(3-methoxybenzenesulfonyl)piperazin-1-yl]ethyl}-2-methylpyrido[1,2-a]pyrimidin-4-one
• Synonyms: 3-{2-[4-(3-methoxybenzenesulfonyl)piperazin-1-yl]ethyl}-2-methylpyrido[1,2-a]pyrimidin-4-one
• CAS NO: 1359976-55-8
• Molecular Weight: 442.539
• Mol File: 1359976-55-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-{2-[4-(3-methoxybenzenesulfonyl)piperazin-1-yl]ethyl}-2-methylpyrido[1,2-a]pyrimidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-{2-[4-(3-methoxybenzenesulfonyl)piperazin-1-yl]ethyl}-2-methylpyrido[1,2-a]pyrimidin-4-one(1359976-55-8)
• EPA Substance Registry System: 3-{2-[4-(3-methoxybenzenesulfonyl)piperazin-1-yl]ethyl}-2-methylpyrido[1,2-a]pyrimidin-4-one(1359976-55-8)

Safety Data

• Hazardous Substances Data: 1359976-55-8(Hazardous Substances Data)

Upstream product

• 517-23-7 3-acetyl-2-oxo-4,5-dihydrofuran 
• 380634-63-9 3-(1-(pyridin-2-ylamino)ethylidene)dihydrofuran-2-(3H)-one 
• 10130-74-2 m-Methoxybenzenesulfonyl chloride 
• 1359976-45-6 2-methyl-3-(2-piperazin-1-yl-ethyl)pyrido[1,2-a]pyrimidin-4-one 

Relevant articles and documents

Synthesis and in vitro antiproliferative activity of 2-methyl-3-(2- piperazin-1-yl-ethyl)-pyrido[1,2-a]pyrimidin-4-one derivatives against human cancer cell lines

A series of new 2-methyl-3-(2-piperazin-1-yl-ethyl)-pyrido[1,2-a]pyrimidin- 4-one derivatives 6a-j were synthesized by a nucleophilic substitution reaction of 2-methyl-3-(2-piperazin-1-ylethyl)-pyrido[1,2-a]pyrimidin-4-one with various sulfonyl chlorides. The compounds were characterized by different spectral studies. All the compounds were evaluated for their antiproliferative effect using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay method against four human cancer cell lines (K562, Colo-205, MDA-MB 231, IMR-32) for the time period of 24 h. Among the series, compounds 6d, 6e and 6i showed good activity on all cell lines except K562, whereas the other compounds in the series exhibited moderate activity. Compound 6d could be a potential anticancer agent and therefore deserves further research.