13600-33-4

Basic information

• Product Name: Pyrimidine, 2-(1H-tetrazol-5-yl)- (8CI,9CI)
• Synonyms: Pyrimidine, 2-(1H-tetrazol-5-yl)- (8CI,9CI);2-(1H-tetrazol-5-yl)pyrimidine(SALTDATA: FREE);2-(1H-tetrazol-5-yl)pyrimidine
• CAS NO: 13600-33-4
• Molecular Formula: C5H4N6
• Molecular Weight: 148.12546
• Product Categories: PYRIMIDINE
• Mol File: 13600-33-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 233 °C
• Boiling Point: 443.8±28.0 °C(Predicted)
• Appearance: /
• Density: 1.493±0.06 g/cm3(Predicted)
• PKA: 2.84±0.10(Predicted)
• CAS DataBase Reference: Pyrimidine, 2-(1H-tetrazol-5-yl)- (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 2-(1H-tetrazol-5-yl)- (8CI,9CI)(13600-33-4)
• EPA Substance Registry System: Pyrimidine, 2-(1H-tetrazol-5-yl)- (8CI,9CI)(13600-33-4)

Safety Data

• Hazardous Substances Data: 13600-33-4(Hazardous Substances Data)

Usage

Description

Pyrimidine, 2-(1H-tetrazol-5-yl)(8CI,9CI) is a chemical compound characterized by the molecular formula C6H4N6. It is a pyrimidine derivative featuring a tetrazole group attached at the 2-position. Pyrimidine, 2-(1H-tetrazol-5-yl)(8CI,9CI) is recognized for its potential applications in the pharmaceutical industry, primarily as a building block for synthesizing a variety of drugs and pharmaceutical compounds. The incorporation of the tetrazole group, known for its bioactive properties, alongside the pyrimidine ring, enhances its utility in medicinal chemistry, making it a promising intermediate for the development of new drugs and therapeutic agents.

Uses

Used in Pharmaceutical Industry:
Pyrimidine, 2-(1H-tetrazol-5-yl)(8CI,9CI) serves as a valuable building block for the synthesis of various pharmaceutical compounds. Its unique structure, which includes both a pyrimidine ring and a tetrazole group, contributes to its potential in creating novel drugs with improved therapeutic properties.
Used in Drug Development:
As an intermediate in drug development, Pyrimidine, 2-(1H-tetrazol-5-yl)(8CI,9CI) aids in the creation of new pharmaceutical agents. The bioactive nature of the tetrazole group, combined with the versatility of the pyrimidine ring, makes this compound instrumental in the design and synthesis of innovative therapeutics.
Further research and development of Pyrimidine, 2-(1H-tetrazol-5-yl)(8CI,9CI) may lead to the discovery of novel drugs or therapeutic agents, particularly those targeting specific medical conditions or diseases. Its role in the pharmaceutical industry is thus multifaceted, encompassing both the synthesis of existing drugs and the exploration of new chemical entities for treatment.

Upstream product

• 14080-23-0 2-cyanopyrimidine 

Relevant articles and documents

Three new alkaline earth coordination compounds based on 5-(2-pyrimidyl)tetrazole-2-acetic acid

Reactions of Hpymtza (Hpymtza = 5-(2-pyrimidyl)tetrazole-2-acetic acid) with MCl2(M = Mg(II), Sr(II), Ba(II)), produced three new coordination compounds, [Mg(H2O)6]·2pymtza·H2O (1), [Sr(pymtza)2(H2O)2]·4H2O (2), [Ba(pymtza)2(H2O)4]·H2O (3), These compounds were characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. Compound 1 shows a mononuclear structure while 2 and 3 reveal 1-D structures via bridging pymtza as linker. Furthermore, the luminescent properties of 1-3 were investigated at room temperature in the solid state.

PH Dependent Synthesis of Two Manganese Compounds based on 5-(2-Pyrimidyl)tetrazole-1-acetic Acid

Reactions of Hpymtza [Hpymtza = 5-(2-pyrimidyl)tetrazole-1-acetic acid] with MnCl2·4H2O under different pH conditions, afforded the complexes [Mn(pymtza)2(H2O)4] (1) and [Mn2(pymtza)2Cl2(EtOH)]·H2O (2). The compounds were structurally characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. Compound 1 shows a mononuclear structure, whereas complex 2 has a 1D chain structure. In compound 1, the pymtza ligand only acts in a monodentate manner to coordinate to one central MnII atom by one carboxylate atom, In 2, pymtza acts as tetradentate ligand to connect three MnII ions. Compounds 1 and 2 display 3D networks by hydrogen bonding interactions. Furthermore, the luminescence properties of Hpymtza as well as compounds 1 and 2 were investigated at room temperature in the solid state.

PROCESS FOR PREPARING 5-SUBSTITUTED-1H-TETRAZOLES IN AQUEOUS BETAINE SOLUTION

The present invention relates to a method for manufacturing 5-substituted-1H-tetrazole in an aqueous betaine solution. More specifically, the present invention relates to a method for manufacturing 5-substituted-1H-tetrazole which comprises: a step of con

The Synthesis of Tetrazoles in Nanometer Aqueous Micelles at Room Temperature

A newly developed nonionic amphiphile (GPGS-1500), a diester composed of a Guerbet alcohol (2-octyldodecan-1-ol), poly(ethylene glycol) 1500 (PEG 1500), and succinic acid esters, has been prepared as an effective nanomicelle-forming species for the synthesis of tetrazoles in water at room temperature.