1360625-61-1

Basic information

• Product Name: 3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline hydrochloride
• Synonyms: 3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline hydrochloride
• CAS NO: 1360625-61-1
• Molecular Weight: 521.511
• Mol File: 1360625-61-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline hydrochloride(1360625-61-1)
• EPA Substance Registry System: 3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline hydrochloride(1360625-61-1)

Safety Data

• Hazardous Substances Data: 1360625-61-1(Hazardous Substances Data)

Upstream product

• 166815-96-9 N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 1360684-74-7 3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline 
• 1360625-59-7 4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-carboxylic acid tert-butyl ester 
• 159182-40-8 quinoline-3-sulfonyl chloride 

Relevant articles and documents

Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor - 5-HT1A/5-HT2A/5-HT7 and D 2/D3/D4 - Agents: The synthesis and pharmacological evaluation

Two series of arylpiperazinyl-alkyl quinoline-, isoquinoline-, naphthalene-sulfonamides with flexible (13-26) and semi-rigid (33-36) alkylene spacer were synthesized and evaluated for 5-HT1A, 5-HT2A, 5-HT6, 5-HT7 and selected compounds for D2, D3, D4 receptors. The compounds with a mixed 5-HT and D receptors profile 16 (N-{4-[4-(3-chlorophenyl)-piperazin-1-yl]-butyl}-3- quinolinesulfonamide) and 36 (4-(4-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]- ethyl}-piperidine-1-sulfonyl)-isoquinoline), displaying antagonistic activity at 5-HT7, 5-HT2A, D2 postsynaptic sites, produced antidepressant-like effects in the forced swim test in mice and showed significant anxiolytic activity in the plus-maze test in rats. The lead compound 36, a multi-receptor 5-HT2A/5-HT7/D2/D 3/D4 agent, also displayed significant antipsychotic properties in the MK-801-induced hyperlocomotor activity in mice.