1360924-15-7Relevant articles and documents
Synthesis of α,β-unsaturated ketones by Pd-catalyzed decarboxylative allylation of α-oxocarboxylates
Rodriguez, Nuria,Manjolinho, Filipe,Gruenberg, Matthias F.,Goossen, Lukas J.
supporting information; experimental part, p. 13688 - 13691 (2012/01/15)
A palladium/p-tolylphosphine system has been developed that catalyzes the extrusion of carbon dioxide from α-oxocarboxylic acid allyl esters, leading to α,β-unsaturated ketones (see scheme). The palladium complex activates the substrate and mediates the carbon-carbon bond formation to give allyl ketones, and subsequent double bond shift to the α,β position. The actual decarboxylation step with formation of the acyl nucleophile is promoted by phosphine.
