13610-02-1Relevant articles and documents
Prototropic rearrangement of 2-propynyl(methyl)amino, 2-propynyloxy, and 2-propynylsulfanyl derivatives of hetarenes under conditions of phase-transfer catalysis: Mechanism and limitations
Rubina,Fleisher,Abele,Popelis,Lukevits
, p. 963 - 967 (2003)
2-Propynyl derivatives of N-methylaniline, phenol, benzenethiol, 2-pyridinethiol, 2-pyrimidinethiol, and 1,3-benzoxazole-2-thiol were synthesized. Under conditions of phase-transfer catalysis, phenyl 2-propynyl sulfide is converted into allenyl phenyl sul
Defining the potential of aglycone modifications for affinity/selectivity enhancement against medically relevant lectins: Synthesis, activity screening, and HSQC-Based NMR Analysis
Rauthu, Subhash R.,Shiao, Tze Chieh,André, Sabine,Miller, Michelle C.,Madej, élodie,Mayo, Kevin H.,Gabius, Hans-Joachim,Roy, René
, p. 126 - 139 (2015)
The emerging significance of lectins for pathophysiological processes provides incentive for the design of potent inhibitors. To this end, systematic assessment of contributions to affinity and selectivity by distinct types of synthetic tailoring of glyco
Affinity Enhancement of Protein Ligands by Reversible Covalent Modification of Neighboring Lysine Residues
Dal Corso, Alberto,Catalano, Marco,Schmid, Anja,Scheuermann, J?rg,Neri, Dario
, p. 17178 - 17182 (2018)
The discovery of protein ligands, capable of forming a reversible covalent bond with amino acid residues on a protein target of interest, may represent a general strategy for the discovery of potent small-molecule inhibitors. We analyzed the ability of di
Unusual absence of FRET in triazole bridged coumarin-hydroxyquinoline, an active sensor forHg2+detection
Chatterjee, Soumit,Dey, Swapan,Hira, Sumit K.,Mondal, Surajit,Nayek, Hari Pada,Patra, Niladri
, p. 1211 - 1221 (2020)
A triazole-bridged coumarin conjugated quinoline sensor has been ‘click’-synthesized by Cu(i) catalyzed Huisgen cycloaddition, and it exhibited high selectivity for toxicHg2+. Surprisingly, no evidence of energy transfer from the quinoline moiety to coumarin has been found, substantiated by time-resolved fluorescence study. The possible binding mode of this sensor toHg2+has been establishedviaNMR study, steady-state and time-resolved fluorescence spectroscopy, which is further supported by TDDFT calculations. The sensor has been found to be cell membrane permeable and non-toxic, and hence is suitable for intracellularHg2+detection.
Synthesis and application of a fluorescent ?turn-off? triazolyl-coumarin-based fluorescent chemosensor for the sensing of fe3+ ions in aqueous solutions
Mama, Neliswa,Battison, Aidan
, p. 59 - 84 (2020)
Two coumarin derivatives containing triazole moieties have been synthesized using “click chemistry” protocol and investigated as chemosensors for the detection of metal ions. These compounds displayed a strong preference for Fe3+ ions with comp
Compound of dipyrrolopyridine structure Preparation method and medical application
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Paragraph 0163-0166, (2021/08/25)
The invention discloses a compound with a dipyrrolo-pyridine structure as well as a preparation method and medical application thereof. The compound provided by the invention has obvious inhibitory activity on JAK family proteins, is an effective JAK inhibitor, and has the prospect of being developed into drugs for inhibiting JAK and further treating diseases.
Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors**
Anantharajan, Jothi,Baburajendran, Nithya,Foo, Klement,Joy, Joma K.,Keller, Thomas H.,Kwek, Perlyn Z.,Li, Rong,Liu, Boping,Poulsen, Anders,Quach, David,Retna, Priya,Tang, Guanghui,Tee, Doris H. Y.,Wee, John L. K.,Yang, Wan-Qi,Yao, Shao Q.,Zhang, Chong-Jing
supporting information, p. 17131 - 17137 (2021/06/28)
Targeted covalent inhibitors have re-emerged as validated drugs to overcome acquired resistance in cancer treatment. Herein, by using a carbonyl boronic acid (CBA) warhead, we report the structure-based design of BCR-ABL inhibitors via reversible covalent targeting of the catalytic lysine with improved potency against both wild-type and mutant ABL kinases, especially ABLT315I bearing the gatekeeper residue mutation. We show the evolutionarily conserved lysine can be targeted selectively, and the selectivity depends largely on molecular recognition of the non-covalent pharmacophore in this class of inhibitors, probably due to the moderate reactivity of the warhead. We report the first co-crystal structures of covalent inhibitor-ABL kinase domain complexes, providing insights into the interaction of this warhead with the catalytic lysine. We also employed label-free mass spectrometry to evaluate off-targets of our compounds at proteome-wide level in different mammalian cells.
