1361231-19-7

Basic information

• Product Name: 5,7-dihydroxy-6-(2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-2-phenyl-4H-chromen-4-one
• CAS NO: 1361231-19-7
• Molecular Weight: 399.446
• Mol File: 1361231-19-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,7-dihydroxy-6-(2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-2-phenyl-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dihydroxy-6-(2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-2-phenyl-4H-chromen-4-one(1361231-19-7)
• EPA Substance Registry System: 5,7-dihydroxy-6-(2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-2-phenyl-4H-chromen-4-one(1361231-19-7)

Safety Data

• Hazardous Substances Data: 1361231-19-7(Hazardous Substances Data)

Upstream product

• 114640-73-2 N-methyl-1-hydroxy-1,2,3,4-tetrahydroisoquinoleine 
• 480-40-0 5,7-dihydroxy-2-phenyl-chromen-4-one 

Relevant articles and documents

An efficient one-step synthesis of piperidin-2-yl and pyrrolidin-2-yl flavonoid alkaloids through phenolic Mannich reactions

An efficient one-step synthesis of piperidin-2-yl and pyrrolidin-2-yl flavonoid alkaloids was achieved in good to excellent yields by a highly regioselective phenolic Mannich reaction of chrysin with cyclic imines or iminium salts. Performing the reaction in a mixture of H2O/THF in the absence of an external reagent afforded the C-6 alkylated product exclusively. The same reaction in water in the presence of NaOH provided the C-8 alkylated flavonoid as a major product. The reaction has been successfully extended to simple phenols.