1361321-96-1 Usage
Description
(S)-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid (3,5-dimethyl-phenyl)-amide, also known as ACT-462206, is a potent and selective dual orexin receptor antagonist (DORA). It is a pharmaceutical compound that specifically inhibits the stimulating effects of orexin peptides at both the orexin 1 and 2 receptors. (S)-1-(4-methoxy-benzenesulfonyl)-pyrrolidine-2-carboxylicacid (3,5-dimethyl-phenyl)-amide has been synthesized to address sleep disorders and other related conditions by modulating the wakefulness and sleep patterns in a controlled manner.
Uses
Used in Pharmaceutical Industry:
ACT-462206 is used as a therapeutic agent for the treatment of sleep disorders. It works by decreasing wakefulness and increasing both non-rapid eye movement (non-REM) and REM sleep, thus helping to regulate sleep patterns in patients. The compound maintains natural sleep architectures in some animal models, making it a promising candidate for further research and development in the treatment of sleep-related conditions.
Used in Neurological Applications:
In addition to its sleep-regulating properties, ACT-462206 has also shown anxiolytic-like properties in certain animal models without affecting cognition and motor function. This suggests that the compound may have potential applications in the treatment of anxiety disorders and other neurological conditions related to the orexin system.
Used in Research and Development:
ACT-462206 serves as an important research tool for understanding the role of the orexin system in sleep regulation, anxiety, and other related conditions. By studying the effects of this compound on orexin receptors, researchers can gain valuable insights into the underlying mechanisms of these disorders and develop more targeted and effective treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 1361321-96-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,1,3,2 and 1 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1361321-96:
(9*1)+(8*3)+(7*6)+(6*1)+(5*3)+(4*2)+(3*1)+(2*9)+(1*6)=131
131 % 10 = 1
So 1361321-96-1 is a valid CAS Registry Number.
1361321-96-1Relevant articles and documents
Short synthesis of a proline amide orexin receptor antagonist on the pilot plant scale
Tortoioli, Simone,Marchal, Daniel,Kesselgruber, Martin,Pabst, Thomas,Skranc, Wolfgang,Abele, Stefan
, p. 1759 - 1762 (2014)
A three-step fully telescoped synthesis of an N-sulfonyl proline amide, a nonpeptide antagonist of human orexin receptors, is described. The process development from the medicinal chemistry route up to the 240 kg production of 1 is discussed with a focus
Structure-Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT-462206: A Potent, Brain-Penetrant Dual Orexin1/Orexin2 Receptor Antagonist
Boss, Christoph,Roch-Brisbare, Catherine,Steiner, Michel A.,Treiber, Alexander,Dietrich, Hendrik,Jenck, Francois,Vonraumer, Markus,Sifferlen, Thierry,Brotschi, Christine,Heidmann, Bibia,Williams, Jodi T.,Aissaoui, Hamed,Siegrist, Romain,Gatfield, John
supporting information, p. 2486 - 2496 (2015/08/24)
The orexin system consists of two G-protein-coupled receptors, the orexin1 and orexin2 receptors, widely expressed in diverse regions of the brain, and two peptide agonists, orexinA and orexinB, which are produced in a small assembly of neurons in the lat
