1361381-84-1Relevant articles and documents
Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy
Demizu, Yosuke,Okuhira, Keiichiro,Motoi, Hiromi,Ohno, Akiko,Shoda, Takuji,Fukuhara, Kiyoshi,Okuda, Haruhiro,Naito, Mikihiko,Kurihara, Masaaki
, p. 1793 - 1796 (2012/04/04)
We designed and synthesized estrogen receptor (ER) degradation inducers 5, 6, and 7, which crosslink the ER and the cellular inhibitor of apoptosis protein 1 (cIAP1). Compounds 5, 6, and 7 induced cIAP1-mediated ubiquitylation of ERa resulting in its proteasomal degradation.