136247-18-2

Basic information

• Product Name: N-(p-Nitrophenethyl)spiperone
• Synonyms: N-(p-Nitrophenethyl)spiperone;8-[4-(4-Fluorophenyl)-4-oxobutyl]-3-[2-(4-nitrophenyl)ethyl]-1-phenyl- 1,3,8-triazaspiro[4.5]decan-4-one
• CAS NO: 136247-18-2
• Molecular Formula: C₃₁H₃₃FN₄O₄
• Molecular Weight: 544.62
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 136247-18-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Refractive Index: 1.651
• Storage Temp.: Refrigerator
• Solubility: Acetone, Chloroform
• CAS DataBase Reference: N-(p-Nitrophenethyl)spiperone(CAS DataBase Reference)
• NIST Chemistry Reference: N-(p-Nitrophenethyl)spiperone(136247-18-2)
• EPA Substance Registry System: N-(p-Nitrophenethyl)spiperone(136247-18-2)

Safety Data

• Hazardous Substances Data: 136247-18-2(Hazardous Substances Data)

Usage

Chemical Properties

Brown-Yellow Oil

Uses

Different sources of media describe the Uses of 136247-18-2 differently. You can refer to the following data:
1. Analogue of Spiperone
2. Analogue of Spiperone.

InChI:InChI=1/C31H33FN4O4/c32-26-12-10-25(11-13-26)29(37)7-4-19-33-21-17-31(18-22-33)30(38)34(23-35(31)27-5-2-1-3-6-27)20-16-24-8-14-28(15-9-24)36(39)40/h1-3,5-6,8-15H,4,7,16-23H2

Upstream product

• 5339-26-4 (4-nitrophenyl)ethyl bromide 
• 749-02-0 spiperone 

Downstream Products

• 129298-01-7 3-<2'-<4-<(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino>phenyl>ethyl>-8-<3'-(p-fluorobenzoyl)propyl>-4-oxo-1-phenyl-1,3,8-triazaspiro<4.5>decane 
• 93801-18-4 [125I]-N-(p-Aminophenethyl)spiroperidol 

Relevant articles and documents

Fluorescent Probes for Dopamine Receptors: Synthesis and Characterization of Fluorescein and 7-Nitrobenz-2-oxa-1,3-diazol-4-yl Conjugates of D-1 and D-2 Receptor Ligands

Fluorescent probes have been designed and developed for dopamine D-1 and D-2 receptors.Fluorescein and/or NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)derivatives of PPHT (D-2 agonist), spiperone (D-2 antagonist), SKF 38393 (D-1 agonist), and SKF 83566 (D-1 antagonist) were synthesized via their amino-functionalized analogues and all ligands were pharmacologically evaluated by measuring their ability to displace SCH 23390 and 3H)spiperone from D-1 and D-2 receptor sites in caudate putamen of monkeys (Macaca fascicularis).The fluorescein derivatives of PPHT andSKF 83566 and the NBD derivatives of spiperone and SKF 83566 retained the high affinity and selectivity of parent ligands.The NBD derivatives of PPHT showed higher D-2 receptor affinity and selectivity than their parent ligands.The enantiomers of the fluorescent derivatives of PPHT were also synthesized and were found to exhibit stereoselectivity in binding to the D-2 receptor, with the S enantiomers having a considerably higher affinity than their R analogues.In contrast to these results, the fluorescein derivative of SKF 38393 showed only a low affinity for the D-1 receptor.These fluorescein- and NBD-coupled D-1 and D-2 receptor ligands have considerable significance as potential probes in the study of distribution of the receptors at the cellular/subcellular level and of their mobility in membranes in normal/diseased states by use of fluorescence microscopic and fluorescence photobleaching recovery techniques, respectively.The development of these novel fluorescent probes should also provide new leads for the design and synthesis of additional fluorescent ligands with better fluorescent properties and/or higher affinity/selectivity for the DA receptors.