13626-76-1

Basic information

• Product Name: 3-methyl-4-phenyloxazol-2(3H)-one
• Synonyms: 3-methyl-4-phenyloxazol-2(3H)-one
• CAS NO: 13626-76-1
• Molecular Weight: 175.187
• Mol File: 13626-76-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-methyl-4-phenyloxazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-4-phenyloxazol-2(3H)-one(13626-76-1)
• EPA Substance Registry System: 3-methyl-4-phenyloxazol-2(3H)-one(13626-76-1)

Safety Data

• Hazardous Substances Data: 13626-76-1(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 34375-80-9 4-phenyl-4-oxazoline-2-one 
• 74-88-4 methyl iodide 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 13098-06-1 4-hydroxy-3-methyl-4-phenyl-oxazolidin-2-one 
• 13098-04-9 2-methylcarbamoyloxy-1-phenyl-ethanone 

Downstream Products

• 152547-73-4 (4R)-methyl-(5S)-phenyl-2-oxazolidinone 

Relevant articles and documents

Spiro[indene-1,4′-oxa-zolidinones] Synthesis via Rh(III)-Catalyzed Coupling of 4-Phenyl-1,3-oxazol-2(3 H)-ones with Alkynes: A Redox-Neutral Approach

Transition-metal-catalyzed C-H activation synthesis of heterocyclic spiro[4,4]nonanes has persistently witnessed the use of additional stoichiometric transition-metal oxidant when employing C=C bond as the spiro ring closure site. Herein, we have addressed the issue by reporting a redox-neutral strategy for spiro[indene-1,4′-oxa-zolidinones] synthesis via Rh(III)-catalyzed coupling of 4-phenyl-1,3-oxazol-2(3H)-ones with alkynes. The synthesis features a broad substrate scope and high regiospecificity.