136309-02-9Relevant articles and documents
Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors
More, Kunal N.,Hong, Victor S.,Lee, Ahyeon,Park, Jongsung,Kim, Shin,Lee, Jinho
supporting information, p. 2513 - 2517 (2018/06/06)
Pim kinases are promising therapeutic targets for the treatment of hematological cancers. A potent Pim kinase inhibitor 7f, derived from meridianin C, was further optimized by the replacement of 2-aminopyrimidine with substituted benzene. The optimization of the C-3 and C-5 positions of indole yielded compound 43 with improved cellular potency and high selectivity against a panel of 14 different kinases.
Pim kinase inhibitory and antiproliferative activity of a novel series of meridianin C derivatives
More, Kunal N.,Jang, Hyo Weon,Hong, Victor S.,Lee, Jinho
supporting information, p. 2424 - 2428 (2014/05/20)
A novel series of meridianin C derivatives substituted at C-5 position were prepared. These derivatives were tested for their kinase inhibitory potencies against all three family members of the pim kinases (Pim-1, Pim-2 and Pim-3). In addition, their anti