1364394-80-8

Basic information

• Product Name: N‐(3‐ethynylphenyl)formamide
• Synonyms: N‐(3‐ethynylphenyl)formamide
• CAS NO: 1364394-80-8
• Molecular Weight: 145.161
• Mol File: 1364394-80-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N‐(3‐ethynylphenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N‐(3‐ethynylphenyl)formamide(1364394-80-8)
• EPA Substance Registry System: N‐(3‐ethynylphenyl)formamide(1364394-80-8)

Safety Data

• Hazardous Substances Data: 1364394-80-8(Hazardous Substances Data)

Upstream product

• 667-27-6 Ethyl bromodifluoroacetate 
• 54060-30-9 3-acetylenephenylamine 
• 68-12-2 N,N-dimethyl-formamide 
• 124-38-9 carbon dioxide 
• 77287-34-4 formamide 
• 767353-37-7 3-(trimethylsilylethynyl)formanilide 

Downstream Products

• 54060-30-9 3-acetylenephenylamine 
• 1364394-84-2 C₁₈H₁₂N₂O₂ 
• 767353-38-8 1,4-bis[3'-formamidophenylethynyl]-2-nitrobenzene 
• 1364394-82-0 C₁₅H₉BrN₂O₃ 

Relevant articles and documents

HCl-mediated transamidation of unactivated formamides using aromatic amines in aqueous media

We report transamidation protocol to synthesize a range of secondary and tertiary amides from weakly nucleophilic aromatic and hetero-aryl amines with low reactive formamide derivatives, utilizing hydrochloric acid as catalyst. This current acid mediated strategy is beneficial because it eliminates the need for a metal catalyst, promoter or additives in the reaction, simplifies isolation and purification. Notably, this approach conventionally used to synthesize molecules on gram scales with excellent yields and a high tolerance for functional groups.

Mild and facile synthesis of formamide: Reduction and functionalization of CO2 using NaBH(OAc)3 under atmospheric pressure

An approach for N-formylation of amines was developed using NaBH(OAc)3 as a reductant under an atmospheric pressure of CO2 at 50 °C. The corresponding formylated products of various amines, including aliphatic and aromatic amines, amines with reductive-sensitive nitro groups and alkynyl groups and benzamides were obtained in good to excellent yields, and the possible reaction mechanism was also proposed.

Facile synthesis of functionalized bis(arylethynyl)benzene derivatives via sila-Sonogashira reaction

This article describes a facile synthesis of a new series of symmetrical bis(arylethynyl) benzene derivatives via a one-pot coupling reaction between trialkylsilyl protected arylalkynyes and aryldihalides bearing both electron-withdrawing (EW) and electrondonating groups (ED) in the presence of PdCl2(PPh3)2(5%) / CuI/tetrabutylammonium fluoride / triethylamine / tetrahydrofuran (sila-Sonogashira reaction) at room temperature. Copyright Taylor & Francis Group, LLC.