136440-22-7 Usage
Description
TMIO, also known as a spin trap, is a selective, cell permeable, and non-toxic compound used for capturing peroxynitrite and secondary O-, C-, S-, and N-centered free radicals. It is characterized by its ability to noncovalently bind with nucleic acid probes, interacting with nucleic acids in a unique manner that allows for detection through electron paramagnetic resonance (EPR) techniques. TMIO is an off-white to yellow crystalline solid.
Uses
Used in Antioxidant Applications:
TMIO is used as an antioxidant agent for its ability to trap peroxynitrite and secondary free radicals, which are known to cause cellular damage and contribute to various diseases.
Used in Nucleic Acid Research:
TMIO is used as a research tool in the field of nucleic acid studies for its unique interaction with DNA and RNA, allowing for the detection of complementary base pairing through EPR techniques.
Used in Pharmaceutical Industry:
TMIO is used as a potential therapeutic agent in the pharmaceutical industry due to its antioxidant properties and ability to neutralize harmful free radicals.
Used in Diagnostic Applications:
TMIO is used as a diagnostic tool for detecting the presence of specific nucleic acid sequences through its interaction with DNA and RNA, which can be detected using EPR techniques.
Used in Chemical Synthesis:
TMIO is used as a reagent in chemical synthesis processes, particularly in the development of new compounds with potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 136440-22-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,4,4 and 0 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 136440-22:
(8*1)+(7*3)+(6*6)+(5*4)+(4*4)+(3*0)+(2*2)+(1*2)=107
107 % 10 = 7
So 136440-22-7 is a valid CAS Registry Number.
136440-22-7Relevant articles and documents
SYNTHESIS OF 2H-IMIDAZOLE 1-OXIDES AND STABLE NITROXYL RADICALS BASED ON THEM
Kirilyuk, I. A.,Grigor'ev, I. A.,Volodarskii, L. B.
, p. 1871 - 1879 (2007/10/02)
2H-Imidazole 1-oxides containing an aldonitrone group in the heterocyclic ring are obtained by the condensation of hydroxyiminomethyl ketones with ketones and ammonium acetate.Their oxidation with lead dioxide in methanol gives stable nitroxyl radicals -
