1364740-54-4

Basic information

• Product Name: C₂₂H₁₃ClF₅NO₃
• CAS NO: 1364740-54-4
• Molecular Weight: 469.795
• Mol File: 1364740-54-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₃ClF₅NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₃ClF₅NO₃(1364740-54-4)
• EPA Substance Registry System: C₂₂H₁₃ClF₅NO₃(1364740-54-4)

Safety Data

• Hazardous Substances Data: 1364740-54-4(Hazardous Substances Data)

Upstream product

• 675139-66-9 ethyl [4-chloro-2-(3-fluoro-5-trifluoromethylbenzoyl)phenoxy]acetate 
• 329946-87-4 [4-chloro-2-(3-fluoro-5-trifluoromethylbenzoyl)phenoxy]acetic acid 
• 329941-92-6 (5-chloro-2-methoxyphenyl)[3-fluoro-5-(trifluoromethyl)phenyl]methanone 
• 329941-93-7 (5-chloro-2-hydroxyphenyl)[3-fluoro-5-(trifluoromethyl)phenyl]methanone 
• 329941-91-5 3-fluoro-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide 
• 171243-30-4 3-fluoro-5-trifluoromethylbenzoyl chloride 
• 29568-33-0 2-methoxy-5-chlorobenzoyl chloride 
• 443-86-7 3-fluoro-2-methylaniline 
• 623-12-1 4-chloromethoxybenzene 
• 1364739-96-7 2-fluoro-3-methyl-4-aminophenyl iodide TsOH salt 
• 875145-55-4 2-fluoro-3-methyl-4-(acetyl)aminophenyl iodide 
• 1364739-71-8 2-fluoro-3-methyl-4-(isobutyryl)aminophenyl iodide 
• 329927-16-4 2-fluoro-3-methyl-4-aminophenyl iodide 
• 1206680-26-3 C₉H₁₀FNO₂ 

Relevant articles and documents

Practical synthesis of a benzophenone-based NNRT inhibitor of HIV-1

A convergent synthesis of NNRTI 1 is described. The key step involves a direct coupling of acid chloride 4 with Grignard reagent 11 in the presence of bis[2-(N,N-dimethylamino)ethyl] ether that moderates the reactivity of the Grignard reagent to give benzophenone 7. An efficient 2-step process for the preparation of 2-fluoro-3-methyl-4-aminobenzoic acid (3) is also described.