136476-38-5 Usage
Chemical compound
A substance formed by the chemical combination of two or more elements in a fixed proportion.
Used in organic synthesis
Organic synthesis is the process of chemically creating organic compounds, which are primarily made of carbon and hydrogen.
Reagent and intermediate
A reagent is a substance or compound used to produce a chemical reaction, while an intermediate is a compound that is produced during a chemical reaction and can be used to make other compounds.
Derivative of cyclopropane
A derivative is a compound that is structurally related to another compound, in this case, cyclopropane.
Contains two methanesulfonate groups
Methanesulfonate groups are chemical groups that contain a methane molecule bonded to a sulfonic acid group.
Preparation of cyclopropane derivatives
Cyclopropane derivatives are compounds that are structurally related to cyclopropane and have similar chemical properties.
Synthesis of various organic compounds
The process of chemically creating organic compounds.
Used as a reagent in the production of pharmaceuticals and other fine chemicals
Pharmaceutical and fine chemicals are high-purity chemicals used in the production of drugs, fragrances, and other products.
Reactivity and specificity
Reactivity refers to the tendency of a substance to undergo a chemical reaction, while specificity refers to the ability of a compound to selectively react with certain other compounds.
Important compound in organic chemistry
This indicates that 1,1-CyclopropanediMethanol diMethanesulfonate is a significant and widely used compound in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 136476-38-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,4,7 and 6 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 136476-38:
(8*1)+(7*3)+(6*6)+(5*4)+(4*7)+(3*6)+(2*3)+(1*8)=145
145 % 10 = 5
So 136476-38-5 is a valid CAS Registry Number.
136476-38-5Relevant articles and documents
Newman et al.
, p. 2890,2892 (1972)
A Spiroalkylation Method for the Stereoselective Construction of α-Quaternary Carbons and Its Application to the Total Synthesis of (R)-Puraquinonic Acid
Elmehriki, Adam A. H.,Gleason, James L.
, p. 9729 - 9733 (2019/12/02)
Cyclic α-quaternary carbon stereocenters were prepared from biselectrophillic substrates and an easily prepared chiral bicyclic sulfonyl lactam. This was achieved in two steps by spiroalkylation, employing biphasic reaction conditions with a phase-transfer catalyst, followed by reduction and alkylation with a series of alkyl halide electrophiles. The products of this method were isolated in good yields with with high levels of diastereoselectivity. This methodology was employed in the enantioselective total synthesis of (R)-puraquinonic acid (1) for a late-stage installation of the α-quaternary carbon stereocenter. This enabled the shortest synthesis of 1 to date, an eight-pot sequence providing an overall yield of 14%.
NOVEL COMPOUNDS FOR MODULATION OF ROR-GAMMA ACTIVITY
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Paragraph 00451; 00454, (2014/03/22)
The present invention relates to aryl sulfones and related compounds that are modulators of ROR-gamma receptors. The invention also provides pharmaceutical compositions comprising these modulators, and methods of modulating ROR-gamma receptors using them. Also provided are methods of using aryl sulfones and related compounds as modulators of ROR-gamma to treat ROR-gamma mediated diseases
