13652-13-6

Basic information

• Product Name: 2,2,2-trifluoro-1-phenylethyl 4-methylbenzenesulfonate
• Synonyms: 2,2,2-Trifluoro-1-phenylethyl 4-methylbenzenesulfonate; 2,2,2-Trifluoro-1-phenylethyl p-toluenesulfonate
• CAS NO: 13652-13-6
• Molecular Formula: C₁₅H₁₃F₃O₃S
• Molecular Weight: 330.3221
• Mol File: 13652-13-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 411.8°C at 760 mmHg
• Flash Point: 202.9°C
• Density: 1.33g/cm³
• Vapor Pressure: 1.29E-06mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: 2,2,2-trifluoro-1-phenylethyl 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-1-phenylethyl 4-methylbenzenesulfonate(13652-13-6)
• EPA Substance Registry System: 2,2,2-trifluoro-1-phenylethyl 4-methylbenzenesulfonate(13652-13-6)

Safety Data

• Hazardous Substances Data: 13652-13-6(Hazardous Substances Data)

Usage

General Description

2,2,2-trifluoro-1-phenylethyl 4-methylbenzenesulfonate is a chemical compound with the molecular formula C16H15F3O3S. It is a sulfonate ester derivative, with a trifluoromethyl group and a phenylethyl moiety attached to a 4-methylbenzenesulfonate group. 2,2,2-trifluoro-1-phenylethyl 4-methylbenzenesulfonate is commonly used as a reagent or intermediate in organic synthesis, particularly in the pharmaceutical industry for the production of various drugs and biologically active compounds. It is also used in the field of agrochemicals and as a building block for the synthesis of other complex organic molecules. The chemical structure of 2,2,2-trifluoro-1-phenylethyl 4-methylbenzenesulfonate allows for versatile reactivity and applications in chemical reactions and processes.

Upstream product

• 340-04-5 1-phenyl-2,2,2-trifluoromethylethanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 86669-62-7 α-Tosyloxy-α-(trifluoromethyl)phenylacetonitrile 
• 434-45-7 2,2,2-Trifluoroacetophenone 

Downstream Products

• 390-75-0 2-fluoro-1,1-diphenylethene 
• 1262431-40-2 1-(2-fluoro-1-phenylvinyl)-4-(trifluoromethyl)benzene 
• 1262431-38-8 (Z)-4-(2-fluoro-1-phenylvinyl)benzonitrile 
• 1262431-39-9 (E)-4-(2-fluoro-1-phenylvinyl)benzonitrile 
• 1262431-37-7 2-(2-fluoro-1-phenylvinyl)naphthalene 
• 1262431-43-5 2-(2-fluoro-1-phenylvinyl)naphthalene 
• 1262431-35-5 (E)-2-fluoro-1-phenylvinyl 4-methylbenzenesulfonate 
• 1262431-36-6 (Z)-2-fluoro-1-phenylvinyl 4-methylbenzenesulfonate 
• 1256278-62-2 2,2-difluoro-1-phenylvinyl 4-methylbenzenesulfonate 
• 657-84-1 sodium tosylate 
• 434-42-4 1,1,1-trifluoro-2-bromo-2-phenylethane 
• 21249-93-4 (2,2,2-trifluoroethyl)benzene 

Relevant articles and documents

Synthesis of α-(trifluoromethyl)phenylacetonitrile. Anomalous reactions of α-tosyloxy-α-(trifluoromethyl)phenylacetonitrile with sodium borohydride

The hitherto unknown α-(trifluoromethyl)phenylacetonitrile has been synthesized by reduction of the cyanohydrin of α,α,α-trifluoroacetophenone.Sodium borohydride reduction of the corresponding cyanohydrin tosylate resulted in reductive decyanation in dimethyl sulphoxide and in reduction of the nitrile group in t-butanol. - Keywords: Synthesis; α-(Trifluoromethyl)phenylacetonitrile; Anomalous reactions; Sodium borohydride; NMR spectroscopy; IR spectroscopy, Mass spectrometry

Profiling sulfonate ester stability: Identification of complementary protecting groups for sulfonates

(Figure presented) Sulfonation is prized for its ability to impart water-solubility to hydrophobic molecules such as dyes. This modification is usually performed as a final step, since sulfonated molecules are poorly soluble in most organic solvents, which complicates their synthesis and purification. This work compares the intrinsic lability of different sulfonate esters, identifying new sulfonate protecting groups and mild, selective cleavage conditions.

Proton-Transfer Reactions. 2. Effects of Internal Return on Reactivity Difference between Alkoxide-Promoted Eliminations in tert-Butyl alcohol and Ethyl Alcohol

Kinetics of alkoxide-promoted dehydrofluorination reactions are reported for the series C6H5CH2CH2F (I), C6H5CH2CHF2 (II), C6H5CH2CF3 (III), and C6H5CH2CF2CF3 (V).Rates and activation parameters 3 (M-1 s-1)(50 deg C), ΔH* (kcal mol-1), and ΔS*, (eu)> are respectively: (a) using potassium tert-butoxide in tert-butyl alcohol, I (1.88 * 10-4, 19.1, -16.8), II (1.18 * 10-3, 20.3, -9.3), III (2.15 * 10-3, 22.1, -2.4), V (3.93 * 10-2, 16.9, -12.7); and (b) using sodium ethoxide in ethanol, I (1.32 * 10-6, 25.6, -6.5), II (5.28 * 10-7, 29.7, 3.0), III (3.45 * 10-7, 32.6, 12.5), V (5.41 * 10-5, 27.7, 7.6).The variation in tert-butoxide:ethoxide ratios of 140 (I), 2200 (II), 6200 (III), and 730 (V) are discussed in terms of a two-step mechanism with varying amounts of internal return for II, III, and V.Differences in reactivity for groups attached to the benzylic carbon (-CF3, -CF2Cl, -CHF2, -CF2CF3) and variation of ΔS* values for these reactions are also discussed in terms of a two-step mechanism.