136586-99-7

Basic information

• Product Name: AMINOTRIESTER
• Synonyms: DI-TERT-BUTYL 4-AMINO-4-[2-(TERT-BUTOXYCARBONYL)ETHYL]HEPTANEDIOATE;DI-T-BUTYL 4-[2-(T-BUTOXYCARBONYL)ETHYL]-4-AMINOHEPTANEDICARBOXYLATE;DI-TERT-BUTYL 4-AMINO-4-[2-(TERT-BUTOXYCARBONYL)ETHYL]HEPTANEDIOATEDENDRON P3;AMINOTRIESTER;DENDRON P3
• CAS NO: 136586-99-7
• Molecular Formula: C₂₂H₄₁NO₆
• Molecular Weight: 415.56
• Product Categories: Dendrimers;Dendron;Newkome Dendrimers
• Mol File: 136586-99-7.mol
• Article Data: 20

Chemical Properties

• Melting Point: 62-64 °C
• Boiling Point: 471.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.023±0.06 g/cm3(Predicted)
• PKA: 8.72±0.25(Predicted)
• CAS DataBase Reference: AMINOTRIESTER(CAS DataBase Reference)
• NIST Chemistry Reference: AMINOTRIESTER(136586-99-7)
• EPA Substance Registry System: AMINOTRIESTER(136586-99-7)

Safety Data

• Hazardous Substances Data: 136586-99-7(Hazardous Substances Data)

Usage

Description

AMINOTRIESTER is a versatile chemical compound that serves as a crucial research intermediate in the development of well-defined multifunctional dendrimers. These dendrimers have significant potential in the field of theranostics, which combines therapeutics and diagnostics for personalized medicine.

Uses

Used in Theranostics Research:
AMINOTRIESTER is used as a research intermediate for the construction of multifunctional dendrimers. These dendrimers are designed to enhance the capabilities of theranostics by providing a well-defined structure that can be tailored for specific applications in personalized medicine. The use of AMINOTRIESTER in this context allows for the development of more effective and targeted therapies, as well as improved diagnostic tools for early detection and monitoring of diseases.

Upstream product

• 75-52-5 nitromethane 
• 1663-39-4 tert-Butyl acrylate 
• 136587-00-3 di-tert-butyl 4-<2-(tert-butoxycarbonyl)ethyl>-4-nitroheptanedicarboxylate 

Downstream Products

• 918876-49-0 4-(2-tert-butoxycarbonyl-ethyl)-4-[6-(4-methoxy-phenoxy)-hexanoylamino]-heptanedioic acid di-tert-butyl ester 
• 945744-14-9 di-tert-butyl 4-benzyloxycarbonylamino-4-[2-(tert-butoxycarbonyl)ethyl]-heptanedioate 
• 1607834-34-3 C₁₈₄H₂₂₄N₆O₃₆ 
• 926649-26-5 N-[tris(2-dodecylaminocarbonyl-ethyl)methyl]-N'-[tris(2-tert-butoxycarbonyl-ethyl)methyl]terephthaldiamide 
• 263843-49-8 4-{3-[3-tert-butoxycarbonyl-1,1-bis-(2-tert-butoxycarbonyl-ethyl)-propylcarbamoyl]-5-nitro-benzoylamino}-4-(2-tert-butoxycarbonyl-ethyl)-heptanedioic acid di-tert-butyl ester 
• 880359-78-4 4-(6-benzyloxycarbonylamino-hexanoylamino)-4-(2-tert-butoxycarbonyl-ethyl)-heptanedioic acid di-tert-butyl ester 
• 1217553-84-8 4-(2-tert-butoxycarbonyl-ethyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-heptanedioic acid di-tert-butyl ester 
• 209679-61-8 N-{tris[(2-tert-butoxycarbonyl)ethyl]methyl}-5-nitroisophthalimide monocarboxylic acid 
• 220215-00-9 N,N',N''-tris[tris(2-tert-butoxycarbonyl-ethyl)methyl]-3,3',3''-(1-nitromethanetriyl)tripropanamide 

Relevant articles and documents

Cascade Polymers: Syntheses and Characterization of One-Directional Arborols Based on Adamantane

Several methods for the synthesis of cascade polymers (dendritic macromolecules) on adamantane have been investigated.The synthesis of two novel, branched monomers, 4-amino-4-(3-acetoxypropyl)-1,7-diacetoxyheptane and di-tert-butyl 4-amino-4-heptanedioate, possessing 3-fold symmetry and branches emanating from a tetrahedral carbon branch point, is described.These monomers were reacted with a mono-functional adamantane core to evaluate the reaction efficiency, ease of purification of products, and spectral characteristics.

Generation effect of Newkome dendrimers on cellular uptake

Poly(amide)-based dendrimers can be used as delivery scaffolds in conjunction with the cell-penetrating peptide gH625 derived from the glycoprotein of the Herpes Simplex virus type 1. In this contribution, we aim to isolate the optimal dendrimer generation for cellular uptake for Newkome type dendrimers conjugated with gH625. For this study, we synthesized generations zero to three of the Newkome dendrimer-gH625 bioconjugate. Fluorescent microscopy experiments showed that the second and third generations are the most efficient for cellular uptake with the second generation having the synthetic advantage. The optimal second generation can be used as an improved material for a dendrimer based delivery scaffold for peptide therapeutics.

Synthesis and spectroscopic characterization of a new tripodal hexadentate iron chelator incorporating catechol units

We report the synthesis and physicochemical properties of a new tripodal hexadentate chelator (catTHC) synthesized by reaction of a flexible tripodal backbone with three bidentate catechol units. To improve the efficiency of the amide coupling reaction, classical conditions using two pairs of coupling reactants were tested, and a significant reduction in reaction time was achieved by using microwave irradiation with the reactants DCC/HOBt. Subsequent removal of the benzyl protecting groups using BCl3 in dichloromethane provided the final chelator in good yield. The acid-base properties of catTHC in aqueous solution and the affinity of the ligand towards iron(III) were investigated at variable pH and in the presence of iron(III) using spectroscopic methods. The hexadentate ligand forms a 1:1 complex with iron(III) whose stability constant was determined by competition with EDTA. The values obtained for the stability constant and pFe3+ are log β110 = 36.70 and pFe3+ = 26.7.

Multifunctional degradable nanoparticles with control over size and functionalities

In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymers and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Platform Synthetic Lectins for Divalent Carbohydrate Recognition in Water

Biomimetic carbohydrate receptors (“synthetic lectins”) have potential as agents for biological research and medicine. However, although effective strategies are available for “all-equatorial” carbohydrates (glucose, etc.), the recognition of other types of saccharide under natural (aqueous) conditions is less well developed. Herein we report a new approach based on a pyrene platform with polar arches extending from aryl substituents. The receptors are compatible with axially substituted carbohydrates, and also feature two identical binding sites, thus mimicking the multivalency observed for natural lectins. A variant with negative charges forms 1:2 host/guest complexes with aminosugars, with K1>3000 m?1for axially substituted mannosamine, whereas a positively charged version binds the important α-sialyl unit with K1≈1300 m?1.