1365919-07-8

Basic information

• Product Name: C₁₂H₉F₃N₂O
• Synonyms: C₁₂H₉F₃N₂O
• CAS NO: 1365919-07-8
• Molecular Weight: 254.211
• Mol File: 1365919-07-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₉F₃N₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₉F₃N₂O(1365919-07-8)
• EPA Substance Registry System: C₁₂H₉F₃N₂O(1365919-07-8)

Safety Data

• Hazardous Substances Data: 1365919-07-8(Hazardous Substances Data)

Upstream product

• 33252-63-0 5-(trifluoromethyl)-2(1H)-pyridone 
• 1365918-67-7 C₁₂H₇F₃N₂O₃ 
• 1365919-82-9 2-chloro-5-trifluoromethyl-pyridine 

Relevant articles and documents

Synthesis and structure-activity relationship of 5-substituent-2(1H)- pyridone derivatives as anti-fibrosis agents

Pyridone compounds, such as pirfenidone (PFD) and fluorofenidone (AKF-PD), are multi-target anti-fibrotic agents. Using PFD and AKF-PD as the leading compounds, two series of novel (5-substituent)-2(1H)-pyridone compounds were synthesized with the purpose of maintaining multi-targeting property and overcoming the drawbacks of fast metabolism. These derivatives demonstrated good proliferation inhibiting activity against NIH3T3 cells by MTT assay with AKF-PD as the positive control. Compound 5b exhibited a high potent of anti-fibrosis with a IC50 of 0.08 mmol/L about 34 times of AKF-PD. The SAR of pyridone derivatives as anti-fibrosis agents was also discussed.