136624-42-5

Basic information

• Product Name: 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE
• Synonyms: 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE;4-Piperidinecarbonitrile, 4-amino-1-(phenylmethyl)-
• CAS NO: 136624-42-5
• Molecular Formula: C₁₃H₁₇N₃
• Molecular Weight: 215.3
• Mol File: 136624-42-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 358.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.12±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 6.22±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE(136624-42-5)
• EPA Substance Registry System: 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE(136624-42-5)

Safety Data

• Hazardous Substances Data: 136624-42-5(Hazardous Substances Data)

Usage

General Description

4-Amino-1-benzylpiperidine-4-carbonitrile is a chemical compound used in a variety of pharmaceutical applications. It is a piperidine derivative with a benzyl group and a cyano group attached to the carbon atom at the 4-position. 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE is known for its potential as a building block in the synthesis of various pharmaceutical substances, including antipsychotics, antidepressants, and analgesics. Additionally, it has shown potential as a precursor in the production of novel drug candidates. Its structure and functional groups make it a versatile intermediate for the development of new therapeutic agents, making it an important chemical in drug discovery and development.

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 151-50-8 potassium cyanide 
• 143-33-9 sodium cyanide 
• 7677-24-9 trimethylsilyl cyanide 
• 773837-37-9 sodium cyanide 
• 151097-12-0 4-aminomethyl-1-benzylpiperidine-4-ylamine 

Downstream Products

• 235100-99-9 1-benzyl-4-cyano-4-methanesulfonylamidopiperidine 
• 151097-12-0 4-aminomethyl-1-benzylpiperidine-4-ylamine 
• 1160939-53-6 3,5-diamino-6-chloropyrazine-2-carboxylic acid [8-benzyl-1,3,8-triazaspiro[4.5]dec-(2Z)-ylidene]-amide 

Relevant articles and documents

Design and Synthesis of Fsp3-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

The exploration of innovative chemical space is a critical step in the early phases of drug discovery. Bis-spirocyclic frameworks occur in natural products and other biologically relevant metabolites and show attractive features, such as molecular compactness, structural complexity, and three-dimensional character. A concise approach to the synthesis of bis-spirocyclic-based compound libraries starting from readily available commercial reagents and robust chemical transformations has been developed. A number of novel bis-spirocyclic scaffold examples, as implemented in the European Lead Factory project, is presented.

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor

We report the synthesis of rigid spirocyclic systems as conformationally constrained variants of the Ala-Phe-NH2 dipeptide amide C-terminus of the calcitonin gene-related peptide (CGRP). CGRP receptor antagonists containing these moieties displ