136632-32-1

Basic information

• Product Name: 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
• Synonyms: Calpain Inhibitor II, ALLM;ALLM (Calpain Inhibitor) 95% purity;ALLM (Calpain Inhibitor);25 MG CALPAIN INHIBITOR IIRESEARCH GRADE;CALPAIN INHIBITOR II (N-AC-LEU-LEU METHIORINAL);N-acetyl-Leu-Leu-methional
• CAS NO: 136632-32-1
• Molecular Formula: C19H35N3O4S1
• Molecular Weight: 401.56
• EINECS: 603-969-3
• Product Categories: Calpain I;Calpain I Inhibitors;Calpain II;Calpain II Inhibitors;Carbonyl Compounds;Cathepsin B;Cathepsin/Granzyme Inhibitors &C-CH;Cell Biology;Cell Signaling and Neuroscience;Cell Signaling Enzymes;Chemical Synthesis;Endoplasmic Reticulum Stress;Enzyme Inhibitors;Enzyme Inhibitors by Enzyme;Enzymes;Inhibitors;Intracellular Protein Degradation;Lysosomal Proteases;Substrates;ProteasomeInhibitors;Protease;Nitric Oxide and Cell;A to C;Aldehydes;and Substrates;Apoptosis Enzymes;Application Index;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;C13-C60;Calpain;Calpain and Proteasome Inhibitors
• Mol File: 136632-32-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 676.5°C at 760 mmHg
• Flash Point: 362.9°C
• Appearance: white/
• Density: 1.076g/cm³
• Vapor Pressure: 3.69E-18mmHg at 25°C
• Refractive Index: 1.495
• Storage Temp.: −20°C
• Solubility: Soluble in ethanol at 20mg/ml
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
• BRN: 7693643
• CAS DataBase Reference: 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE(CAS DataBase Reference)
• NIST Chemistry Reference: 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE(136632-32-1)
• EPA Substance Registry System: 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE(136632-32-1)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 136632-32-1(Hazardous Substances Data)

Usage

Description

25 MG CALPAIN INHIBITOR II (ALLM) is a cell-permeable, peptide aldehyde inhibitor specifically designed to target calpain I and calpain II, which are calcium-activated cysteine proteases. It is a potent inhibitor of cathepsin L and cathepsin B, and also exhibits inhibitory effects on other neutral cysteine proteases, aspartic hemoglobinases, and activation-induced programmed cell death. ALLM is characterized by its cell permeability and ability to restore defective immune responses in HIV+ donors, block nitric oxide production, and weakly inhibit the proteasome.

Uses

Used in Pharmaceutical Research:
25 MG CALPAIN INHIBITOR II (ALLM) is used as a research tool for studying the role of calpain and cathepsin proteases in various cellular processes and diseases. It helps researchers understand the mechanisms of these proteases and their potential as therapeutic targets.
Used in Drug Development:
In the pharmaceutical industry, 25 MG CALPAIN INHIBITOR II (ALLM) is used as a lead compound for the development of new drugs targeting calpain and cathepsin proteases. Its potent inhibitory properties make it a valuable starting point for designing more effective and selective inhibitors.
Used in HIV Research:
25 MG CALPAIN INHIBITOR II (ALLM) is used as a research compound to study its potential in restoring defective immune responses in HIV+ donors, which could lead to the development of new therapeutic strategies for HIV treatment.
Used in Malaria Research:
In the field of infectious disease research, 25 MG CALPAIN INHIBITOR II (ALLM) is used as an inhibitor of malaria aspartic hemoglobinases plasmepsins I and II, providing insights into the potential of targeting these enzymes for antimalarial drug development.
Used in Immunology Research:
25 MG CALPAIN INHIBITOR II (ALLM) is used as a research tool to investigate the role of calpain and cathepsin proteases in immune cell function and activation-induced programmed cell death, contributing to a better understanding of immune system regulation.
Used in Neuroscience Research:
In the neuroscience field, 25 MG CALPAIN INHIBITOR II (ALLM) is used to study the involvement of calpain in neurodegenerative diseases and the potential of calpain inhibition as a therapeutic strategy for conditions such as Alzheimer's disease, Parkinson's disease, and stroke.
Used in Cell Biology Research:
25 MG CALPAIN INHIBITOR II (ALLM) is used as a research reagent to explore the role of calpain and cathepsin proteases in cellular processes such as apoptosis, cell signaling, and protein turnover, providing valuable information for understanding cellular mechanisms and potential therapeutic targets.

References

1) Sasaki?et al.?(1990),?Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins;?J. Enzyme Inhib.,?3?195 2) Vinitsky?et al.?(1992),?Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex; Biochemistry,?31?9421

InChI:InChI=1/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15?,16-,17?/m0/s1