1367075-20-4Relevant articles and documents
Development of a simple system for the oxidation of electron-rich diazo compounds to ketones
O'Connor, Nicholas R.,Bolgar, Peter,Stoltz, Brian M.
, p. 849 - 851 (2016/02/05)
Mild heating of diazo compounds in DMSO furnishes ketone products in moderate to excellent yields. The reaction is particularly effective on electron-rich substrates and exhibits high chemoselectivity, allowing for the use of diazo compounds containing additional oxidation-prone functional groups. This straightforward protocol offers an alternate route to synthetically useful α-ketoesters from readily available aryl diazoacetates.