136721-64-7

Basic information

• Product Name: Acetamide, 2-bromo-N-[2-[(triphenylmethyl)thio]ethyl]-
• CAS NO: 136721-64-7
• Molecular Formula: C23H22BrNOS
• Molecular Weight: 440.404
• Mol File: 136721-64-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Acetamide, 2-bromo-N-[2-[(triphenylmethyl)thio]ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2-bromo-N-[2-[(triphenylmethyl)thio]ethyl]-(136721-64-7)
• EPA Substance Registry System: Acetamide, 2-bromo-N-[2-[(triphenylmethyl)thio]ethyl]-(136721-64-7)

Safety Data

• Hazardous Substances Data: 136721-64-7(Hazardous Substances Data)

Upstream product

• 15297-43-5 <2-<(triphenylmethyl)thio>ethyl>amine hydrochloride 
• 598-21-0 2-Bromoacetyl bromide 
• 1095-85-8 2-amino tritylthio ethane 
• 79-08-3 bromoacetic acid 
• 76-84-6 triphenylmethyl alcohol 

Downstream Products

• 152863-83-7 N-[2-[(triphenylmethyl)thio]ethyl]-2-[[2-[(triphenylmethyl)thio]ethyl]amino]acetamide 
• 228253-41-6 N-[2-(tritylthio)ethylaminocarbonylmethyl]-N-[2-(tritylthio)ethyl]-4-aminobutyric acid 
• 915380-02-8 4-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-butyric acid methyl ester 

Relevant articles and documents

Bisamidate and mixed amine/amidate NiN2S2 complexes as models for nickel-containing acetyl coenzyme A synthase and superoxide dismutase: An experimental and computational study

The distal nickel site of acetyl-CoA synthase (Nid-ACS) and reduced nickel superoxide dismutase (Ni-SOD) display similar square-planar NiIIN2S2 coordination environments. One difference between these two sites,

Prodrug comprising a drug-linker conjugate

The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof comprising a drug linker conjugate D-L, wherein -D is an amine containing biologically active moiety; and -L is a non-biologically active linker moiety -L 1 represented by formula (I), wherein the dashed line indicates the attachment to the amine of the biologically active moiety and wherein R 1 , R 1a , R 2 , R 2a , R 3 , R 3a , X, X 1 , X 2 , X 3 have the meaning as indicated in the description and the claims and wherein L 1 is substituted with one to four groups L 2 -Z and optionally further substituted, provided that the hydrogen marked with the asterisk in formula (I) is not replaced by a substituent; wherein L 2 is a single chemical bond or a spacer; and Z is a carrier group and wherein D-H is a polypeptide selected from the group of polypeptides consisting of exendins, glucagon, glucagon-like peptides and insulins. The invention also relates pharmaceutical composition comprising said prodrugs and their use as medicaments.

Synthesis and biological evaluation of technetium-99m-labeled deoxyglucose derivatives as imaging agents for tumor

Three deoxyglucose (DG) derivatives, S-DG, MAG3-DG and MAMA-BA-DG, were synthesized and labeled successfully with high labeling yields and high radio-chemical purities. Biodistribution in tumor-bearing mice demonstrated that these three new su