136725-55-8 Usage
Description
(R)-(-)-3-FLUOROPYRROLIDINE HYDROCHLORIDE is an organic compound with the molecular formula C4H8FNO.HCl. It is a chiral molecule, with the R-configuration indicating the specific arrangement of atoms in the molecule. (R)-(-)-3-FLUOROPYRROLIDINE HYDROCHLORIDE serves as a key intermediate in the synthesis of various pharmaceutical compounds due to its unique structural properties.
Uses
Used in Pharmaceutical Industry:
(R)-(-)-3-FLUOROPYRROLIDINE HYDROCHLORIDE is used as a synthetic intermediate for the preparation of Imidazo[1,2-a]pyrazine derivatives. These derivatives have potential applications as aurora kinase inhibitors, which are important targets for the development of anticancer drugs. Aurora kinases are overexpressed in various types of cancer, and their inhibition can lead to the suppression of tumor growth and progression.
(R)-(-)-3-FLUOROPYRROLIDINE HYDROCHLORIDE is also used as a synthetic intermediate for the preparation of Pyrazolopyrimidine derivatives. These derivatives are potential PDE10A inhibitors, which have therapeutic applications in the treatment of various central nervous system disorders, such as schizophrenia and Huntington's disease. PDE10A is an enzyme that regulates the levels of cyclic nucleotides, and its inhibition can help restore the balance of these signaling molecules, leading to improved cognitive and motor functions in patients with these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 136725-55-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,7,2 and 5 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 136725-55:
(8*1)+(7*3)+(6*6)+(5*7)+(4*2)+(3*5)+(2*5)+(1*5)=138
138 % 10 = 8
So 136725-55-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H8FN.ClH/c5-6-3-1-2-4-6;/h1-4H2;1H
136725-55-8Relevant articles and documents
Halogen-substituted latrotinib compound
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Paragraph 0060; 0063-0064; 0076-0081, (2021/02/10)
The invention relates to a halogen-substituted latrotinib compound. The halogen-substituted latrotinib compound comprises a latrotinib bisulfate compound labeled by a radioactive halogen atom or a non-radioactive halogen atom. The compound comprises a (R,
KRAS G12C INHIBITORS
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Paragraph 0247-0248, (2020/03/23)
The present invention relates to compounds that, inhibit KRas G12C, In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
A fluorine-substituted pyrrolidinium-based ionic liquid for high-voltage Li-ion batteries
Dzwiniel, Trevor L.,Hsu, Chia-Wei,Liu, Qian,Pupek, Krzysztof Z.,Zhang, Zhengcheng
supporting information, p. 7317 - 7320 (2020/07/14)
A fluorine-substituted ionic liquid based on a pyrrolidinium cation and a bis(fluorosulfonyl)imide anion was synthesized using a facile one-step reaction. The resulting ionic liquid is highly pure and when dissolved with LiFSI, the IL-based electrolyte sh
