13673-62-6

Basic information

• Product Name: 2-Methylthio Benzoxazole
• Synonyms: 2-Methylthio Benzoxazole;7004 2-METHYLTHIOBENZOXAZOLE;2-METHYLTHIO BENZOXAZOLE 99%;2-(Methylthio)benzo[d]oxazole
• CAS NO: 13673-62-6
• Molecular Formula: C₈H₇NOS
• Molecular Weight: 165.21228
• Product Categories: API intermediates
• Mol File: 13673-62-6.mol
• Article Data: 27

Chemical Properties

• Melting Point: 126 °C
• Boiling Point: 122°C/8mmHg(lit.)
• Flash Point: 119ºC
• Appearance: /
• Density: 1.27g/cm3
• Vapor Pressure: 0.00977mmHg at 25°C
• Refractive Index: 1.6120 to 1.6170
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.36±0.10(Predicted)
• CAS DataBase Reference: 2-Methylthio Benzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylthio Benzoxazole(13673-62-6)
• EPA Substance Registry System: 2-Methylthio Benzoxazole(13673-62-6)

Safety Data

• Hazardous Substances Data: 13673-62-6(Hazardous Substances Data)

Usage

General Description

2-Methylthio Benzoxazole is a chemical compound with the molecular formula C9H7NOS. It is a heterocyclic aromatic compound with a benzoxazole ring that contains a methylthio group. 2-Methylthio Benzoxazole is often used in pharmaceutical and organic synthesis as a building block for creating various functional molecules and pharmaceutical drugs. It has been researched for its potential as an antifungal and antimicrobial agent, as well as for its fluorescence properties, making it useful in chemical and biological sensing applications. Its unique structure and properties make 2-Methylthio Benzoxazole a versatile and important chemical in the field of organic chemistry and pharmaceutical research.

InChI:InChI=1/C8H7NOS/c1-11-8-9-6-4-2-3-5-7(6)10-8/h2-5H,1H3

Upstream product

• 2382-96-9 benzo[d]oxazole-2-(3H)-thione 
• 333-27-7 methyl trifluoromethanesulfonate 
• 95-55-6 2-amino-phenol 
• 80-48-8 methyl p-toluene sulfonate 
• 2382-96-9 2-sulfanyl-1,3-benzoxazole 
• 74-88-4 methyl iodide 
• 273-53-0 benzoxazole 
• 14236-72-7 2-methylsulfanyl-1-phenyl-propan-1-one 
• 54648-79-2 N,N’-diisopropyl-O-methylisourea 
• 616-38-6 carbonic acid dimethyl ester 
• 7471-86-5 methyl benzimidate 
• 77-78-1 dimethyl sulfate 
• 108805-12-5 3'-(Dimethylamino)spiroazirin> 
• 54856-83-6 3-dimethylamino-2,2-dimethyl-2H-azirine 

Downstream Products

• 66910-82-5 2-(phenethyloxy)benzoxazole 
• 106018-82-0 24-(methylthio)-5β-cholan-3α-ol 
• 59-49-4 2-hydroxybenzoxazole 
• 24293-19-4 1,2-Bis<(methylthio)methyl>benzene 
• 59-49-4 2-Benzoxazolinone 
• 766-92-7 [(methylthio)methyl]-benzene 
• 95-55-6 2-amino-phenol 
• 273-53-0 benzoxazole 
• 86971-27-9 2-(cyclohexylthio)benzo[d]oxazole 
• 1187772-37-7 2-[(4-trifluoromethylphenyl)ethynyl]benzoxazole 
• 1370422-34-6 2-{(4-fluorophenyl)ethynyl}benzoxazole 
• 1226889-63-9 2-[(4-methoxyphenyl)ethynyl]benzoxazole 
• 1226889-50-4 2-[(2-methylphenyl)ethynyl]benzoxazole 
• 90548-40-6 2-(phenylethynyl)benzo[d]-oxazole 

Relevant articles and documents

SH-methylation of SH-containing heterocycles with dimethyl carbonate via phase-transfer catalytic reaction

A reaction of SH-containing heterocycles with dimethyl carbonate (DMC) in the presence of K2CO3 and tetrabutylammonium bromide (Bu4NBr) gave heteroaryl methyl thioethers in 44-93% yields. The reaction was carried out under mild conditions. This method provided a useful synthetic method for preparation of various heteroaryl methyl thioethers without the use of toxic methylic halides or dimethyl sulfate.

New cyanine dyes as base surrogates in PNA: Forced intercalation probes (FIT-probes) for homogeneous SNP detection

Forced intercalation probes (FIT-probes) are nucleic acid probes, in which an intercalator cyanine dye such as thiazole orange (TO) serves as a replacement of a canonical nucleobase. These probes signal hybridization by showing strong increases of fluorescence. TO in FIT-probes responds to adjacent base mismatches by attenuation of fluorescence intensities at conditions where both matched and mismatched target DNA are bound. The interesting features of TO labeled FIT-probes posed the question whether the forced intercalation concept can be extended to other cyanine dyes of the thiazole orange family. Herein, we present the synthesis of three asymmetrical cyanine dyes and their incorporation into PNA-conjugates by means of both divergent and linear solid-phase synthesis. Melting analysis revealed that the DNA affinity of PNA probes remained high irrespective of the replacement of a nucleobase by the cyanines YO (oxazole yellow), MO or JO. Of the three new tested dye-PNA-conjugates, the YO-containing PNA has properties useful for homogeneous SNP detection. YO-PNA is demonstrated to signal the presence of fully complementary DNA by up to 20-fold enhancement of fluorescence. In addition, YO emission discriminates against single base mismatches by attenuation of fluorescence. Oxazole yellow (YO) as a base surrogate in PNA may prove useful in the multiplex detection of single base mutations at non-stringent conditions.

HMOX1 inducers

The present invention is related to compounds of structure (I) as heme oxygenase 1 (HMOX 1) inducers. The present invention is also related a method of controlling the activity or the amount, or both the activity and the amount, of heme-oxygenase 1 in a mammalian subject. The definitions of the variables are provided herein.

5HT1F RECEPTOR AGONISTS AND MITOCHONDRIAL BIOGENESIS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.