136740-96-0Relevant articles and documents
1,2,5,6-Tetra-O-benzyl-D-mannitol derivatives as novel HIV protease inhibitors
Bouzide, Abderrahim,Sauve, Gilles,Sevigny, Guy,Yelle, Jocelyn
, p. 3601 - 3605 (2007/10/03)
The synthesis and structure-activity relationships of HIV protease inhibitors derived from carbohydrate alditols are discussed. We disclose a new series of 1,2,5,6-tetra-O-alkyl-D-mannitol exhibiting sub-micromolar activity against HIV-protease. This seri
Stereocontrolled synthesis of HIV-1 protease inhibitors with C2-axis of symmetry
Ghosh, Arun K.,McKee, Scan P.,Thompson, Wayne J.
, p. 5729 - 5732 (2007/10/02)
An efficient and stereocontrolled synthesis of various C2-symmetric HIV-1 protease inhibitors is described, starting from commercially available and inexpensive D-mannitol.